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राष्ट्रीय पशु जैव प्रौद्योगिकी संस्थान
National Institute of Animal Biotechnology
An Autonomous Institute of the Department of Biotechnology,
Ministry of Science and Technology, Government of India
राष्ट्रीय पशु जैव प्रौद्योगिकी संस्थान
National Institute of Animal Biotechnology
An Autonomous Institute of the Department of Biotechnology,
Ministry of Science and Technology, Government of India
Dr. Vinod Kumar is an interdisciplinary researcher with a diverse research background. Dr. Kumar received his Doctorate degree (2014) from the Banaras Hindu University, Varanasi, India, in the engineering of advanced carbon nanostructures for various biomedical applications. Thereafter, he underwent for his first postdoctoral training (2014-2016) from the Institute of Nano Science & Technology and developed an expertise in Nano-bio-analytical systems/devices for an early stage screening of cardiac disease biomarkers. Subsequently, he moved to the Ben-Gurion University of the Negev, Israel, where continued expanding his skills in advanced analytical domains i.e. Nanopores, Nano-fluidics etc. During his tenure at Ben-Gurion University of the Negev (2016-2019), he got training in the fabrication and bio-functionalization of nanopore towards improved analytical outcomes for small molecules, and for error-free nucleic acid/ peptide sequencing. Following his return to India (2020), as a senior researcher at the Sanjay Gandhi Postgraduate Institute of Medical Sciences in Lucknow, he began investigating the role of nanomaterials in stem cell engineering, with the goal to develop a pancreatic organoid (as a model system) for understanding the pathophysiology of various environmental diabetogens in Type 2 diabetes, while also designing biopolymer-based edible scaffolds for the development of alternative protein source.
Honors, Awards and Fellowships:
2020-Best Researcher Award in an International Conference on Advanced Nanomaterials, Rama University, Kanpur, India
2020- Senior Demonstratorship, Sanjay Gandhi PGIMS, Lucknow, India
2016-Krietman Postdoctoral Fellowship, Ben Gurion University of the Negev, Israel
2015-SERB-Young Scientist Fast Track grant, SERB-Department of Science & Technology, India
2015-Ruchi Ram Sahni Researcher award in CRIKC Nanoscience Day at Institute of Nano Science & Technology, Mohali, India
2014-Institute of Nano Science & Technology-Postdoctoral Fellowship, Mohali, India
2014-Best Ph. D. thesis presentation award in an International Conference on Recent Advances in Analytic Sciences,
Banaras Hindu University, India
2014-Council of Scientific & Industrial Research-Extended Senior Research Fellowship, India
2014- Vice Chancellor Award for Excellence in Research, Banaras Hindu University, India.
2013-International student exchange fellowship to visit National Tsing Hua University, Taiwan
2007-Junior and Senior Research Fellowship from University Grants Commission, New Delhi, India
Research Interests:
Kumar’s Lab is interested in bringing innovative solutions to livestock health and productivity by introducing next-generation, state-of-the-art model systems and devices. The main focus of the laboratory is to design and develop novel nano-biomaterials based approaches for advanced organoid cultures, and organoid-on-a-chip (BioMEMS) as a novel disease model to understand and develop reliable therapy for complex livestock diseases. Lab is also striving to translate in-house developed cutting-edge micro/nanofluidic technologies into regenerative engineering, 3-D bioprinting, and in bioanalysis, with an end goal of transferring them to the commercial market through collaborations with industry.
Key Research Areas:
1. Development and characterization of organoids as an advanced in vitro 3-D model system
Organoids, miniaturized are 3-D versions of an organ also called “mini-organs” produced in laboratory conditions serve as a model system to study biological functions, diseases, and treatments, more realistically and in greater detail than ever before. Therefore, the primary research goal of the Lab is to develop highly competent organoid model systems for studying the pathophysiology and developing new therapeutic means for complex zoonotic diseases.
2. Nano-biomaterials based strategies to engineer the niche and cell surface for efficient growth of organoid model
The use of well-defined 3-D nano-biomaterials that support and promote organoid formation is an intriguing research topic with the potential to dramatically enhance the reproducibility and relevance of organoids. Synthetic nano-biomaterials can provide modified cell surfaces and a chemically defined milieu or niche that allows exact mimicking of matrix characteristics to affect the cell proliferation and differentiation. Another research goal of the Lab is to create innovative nano-biomaterials for modifying niche and cell surface features to generate efficient organoids models.
3. Organoids-on-a-chip/ 3-D bioprinting
The microfluidic culture device with cells/tissue known as an organ-on-a-chip, these devices can precisely recapitulate the organ-level (multi-tissue) architecture and functions of in vivo organs. Such a system might serve as a reliable model for investigating the disease mechanism in animals and developing innovative therapeutics. As a result, Lab is also interested in developing organoid-on-a-chip devices, first at the single organoid level followed by multi-organoid level, utilizing MEMS technology and 3-D bioprinting. In addition Lab is also interested in synthesis of tunable “bioink” for 3-D bioprinting of organoids and tissue constructs.
4. Nanopore and nanomaterials based novel platforms/devices for disease diagnosis in livestock
Nanopore and nanomaterials-based devices can be conveniently used as portable diagnostic platforms for attaining timely and cost-effective outcomes. Developing nanopore and nanomaterials integrated platforms for high-throughput analysis of pathogens or disease biomarkers of complex zoonotic diseases at an early stages, is another important research area of the Laboratory.
(Published/Accepted)
2022
39. Recent Advances in bioengineered scaffolds for in vitro meat production, Singh, A., Kumar, V., et al. , Cell & Tissue Research, 2022 (Accepted with minor revisions) (IF=4.05)
38. Ti2C-TiO2 MXene nanocomposite based high efficient non-enzymatic glucose sensing platform for diabetes monitoring, Kumar, V., Shukla S.K., Choudhury, M. et al., Sensors, 2022, 22(15), 5589 (IF=3.84)
37. Nanosheets Based Approach to Elevate the Proliferative and Differentiation Efficacy of Human Wharton’s Jelly Mesenchymal Stem Cells, Singh, S.S., Singh, A., Kumar, V., et al., Int. J. Mol. Sci. 2022, 23, 5816, (IF=6.2)
36. Development of RNA-based assay for rapid detection of SARS-CoV-2 in clinical samples, Kumar, V., Mishra, S., Sharma, R, Agarwal, J., Ghosal, U., Khanna, T., Sharma, L. K., Verma, S.K., Tiwari, S., Intervirology,2022, 22;1-7 (IF= 2.25)
2021
35. Dynamic Surface Layer Coiled Coil Proteins Processing Analog-to-Digital Information, Glionna, C., Kumar, V.,* Le Saux, G., Pramanik, B., Wagner, N., Cohen, R. L., Ashkenasy, G., Ashenasy, N., Journal of the American Chemical Society, 2021,143, 42, 17441–17451 (IF= 16.32) (* Equal contributor)
2020
34. Preparation and characterization of Extracellular Vesicles, Tiwari, S., Kumar, V., Randhawa, S., Verma, S., American Journal of Reproductive Immunology, 2020, 85, 1-52 (IF=3.88)
33. Switchable Graphene-Based Bioelectronics Interfaces, Meenakshi; Shukla, S.K.; Narang, J.; Kumar, V.; Govender, P.P.; Niv, A.; Hussain, C.M.; Wang, R.; Mangla, B.; Babu, R.S. Chemosensors 2020, 8, 45 (IF=4.22)
2019
32. Ecotoxic impact assessment of Graphene Oxide on lipid peroxidation at mitochondrial level and redox modulation in fresh water fish Anabas testudineus, Paital, B., Guru, B., Mohapatra, P., Panda, B., Parida, N., Rath, S., Kumar, V*., Saxena, P.S., Srivastava, A., Chemosphere 2019, 224, 796-804 (*Equal contributor) (IF=8.94)
31. Graphene oxide synergistically enhances antibiotic efficacy in Vancomycin resistance Staphylococcus aureus, Singh, V., Kumar, V., Kashyap, S., Singh, A.V., Kishore, V., Sitti, M., Saxena, P. S., Srivastava, A., ACS Applied Biomaterials 2019, 2, 3, 1148-1157 (IF=3.25).
2018
30. Carbon nanostructures (0-3 Dimensional) supported isolated gold nanoparticles as an effective SERS substrate, Abraham, S., Konig, M., Srivastava, S., Kumar, V., Wlakenfort, B., Srivastava, A., Sensor & Actuator B, 2018, 273, 455-465 (IF=9.22)
29. Plasmonic DNA hotspots made from Tungsten disulfide nanosheets and gold nanoparticles for ultrasensitive aptamer-based SERS detection of Myoglobin, Shorie M., Kumar, V*., Kaur, H., Singh, K., Tomar, V., Sabherawal, P. Microchimica Acta 2018,185, 1-7 (IF=5.83) (*Equal contributor)
28. Functionalized MoS2 nanosheets assembled microfluidic immunosensor for highly sensitive detection of food pathogen, Singh, C., Ali, M. A., Kumar, V., Ahmad, R., Sumana, G., Sensor & Actuator B, 2018, 259, 1090-1098 (IF=9.22)
2017
27. One step electro-oxidative preparation of graphene quantum dots from wood charcoal as a peroxidase mimetic, Nirala, N., Kandelwal, G., Kumar, B, Vinita, Kumar, V*. Talanta 2017, 173, 36-43 (IF=6.56)(* Corresponding author)
26. Synergistic Effect of Graphene Oxide Coated Nanotised Apigenin with Paclitaxel (GO-NA/PTX): A ROS Dependent Mitochondrial Mediated Apoptosis in Ovarian Cancer, Pal, M. K.; Jaiswar, S. P.; Dwivedi, A.; Goyal, S.; Dwivedi, V; Pathak, A. K.; Kumar, V.; Sankhwar, P.L.; Ray, R.S.;Anti-Cancer Agents in Medicinal Chemistry, 2017, 17, 1721-1732 (IF=2.5)
25. Microwave Reduced Graphene Oxide as Efficient NIR Photothermal Agent, Kashyap, S., Kumar, V., Abraham, S., Umrao, S., Singh, S., Kamath, A., Rajala, M.S., Srivastava, A., Saxena, P.S., Austin J Biosens & Bioelectron 2017, 3: id1026, 1-5.
24. Sensitive and selective detection of copper ions using low cost nitrogen doped carbon quantum dots as a fluorescent sensing platform, Singh, V., Kumar, V., Yadav, U., Srivastava, R. K. Saxena, P. S., ISSS J Micro Smart Syst., 2017, 1, 1-8.
2016
23. On the stability of surfactant-stabilised few-layer black phosphorus in aqueous media, Brent, J.R., Ganguli, A. K., Kumar, V., Lewis, D., McNaughter, P. D., O’Brien, P., Sabherwal, P.,Tedstone, A. A., RSC Advances 2016, 6, 86955-86958 (IF=4.02).
22. Graphene based Flexible and Stretchable Bioelectronics in Health Care Systems, Kumar, V., Kandelwal, G., Journal of Analytical and Pharmaceutical Research 2016, 3, 1-3.
21. A Nanostructured Aptamer-Functionalised Black Phosphorus Sensing Platform for Label-Free Detection of Myoglobin, a Cardiovascular Disease Biomarker, Kumar, V., Jack R. Brent, J. R., Shorie, S., Kaur, H., Chadha, G., Thomas, A. G., Lewis, E. A., et al., ACS Appl. Mater. Interfaces 2016, 8, 22860−22868 (IF=10.38).
20. Antibody conjugated metal nanoparticle decorated graphene sheets for a mycotoxin sensor, Srivastava, S., Kumar, V., Arora, K., Singh, C., Ali, M. A., Puri, N. K., Malhotra, B. D., RSC Advances 2016, 6, 56516-56526 (IF=4.02).
19. Dipyrrin complex assisted in-situ synthesis of ultra-small gold nanoparticles decorated on partially reduced graphene oxide nanocomposite for efficient catalytic reduction of Cr(VI) to Cr(III), Gupta, R. K., Kumar, V., Srivastava, A., Pandey, D. S., RSC Advances 2016, 6, 40911-40915 (IF=4.02.
2015
18. High-performance and high-sensitivity applications of graphene transistors with self-assembled monolayers, Yeh, C. H., Kumar, V., Wen, S. H., Moyano, D. R., Parashar V., Srivastava, A., Saxena, P. S., Huang, K. P., Chang, C. C., Chiu P. W. Biosensor & Bioelectronics 2015, 77,1008-1015 (IF=12.54).
17. Graphene-CNT nanohybrid aptasensor for label free detection of cardiac biomarker myoglobin, Kumar, V., Shorie M., Sabherawal, P., Ganguli, A., Biosensor & Bioelectronics 2015, 72, 56-60 (IF=12.54).
16. Enhanced electrochemical biosensing efficiency of silica particles supported partially reduced graphene oxide for sensitive detection of cholesterol, Abraham, S., Saurabh Srivastava, S., Kumar, V., Pandey, S., Srivastava, S., Singh, V.N., Shukla,P. K., Saxena, P.S., Srivastava, A. Journal of Electroanalytical Chemistry 2015, 757, 65-72 (IF=4.59)
15. Colorimetric detection of cholesterol based on highly efficient peroxidase mimetic activity of Graphene Quantum Dots, Nirala N.R., Abraham, S., Kumar, V., Bansal A., Srivastava, A., Saxena, P. S., Sensor & Actuators B 2015, 218, 42–50 (IF=9.22).
14. Partially reduced graphene oxide–gold nanorods composite based bioelectrode of improved sensing performance, Nirala N.R., Abraham, S., Kumar, V., Srivastava, M., Srivastava, S. K., Kayastha, A. M.,Saxena, P. S., Srivastava. A. Talanta 2015, 144, 745-754 (IF=6.55).
13. Carbon quantum dots-mediated direct fluorescence assay for the detection of cardiac marker myoglobin, Shorie M., Kumar, V., Sabherawal, P., Ganguli, A., Current Science 2015, 108, 1595-1596 (IF=0.93).
12. In-vitro cytotoxicity assesment of graphene quantum dots in Caprine Wharton’s Jelly derived mesenchymal stem cells Dar, R. M., Gade, N.E., Mishra, O.P., Khan J.R., Kumar V., Patyal, A. Journal of Cell and Tissue Research 2015, 15, 4703-4710.
11. Single molecule detection using nanopore technology, Kumar, V. Editorial, Research & Reviews: Journal of Pharmaceutics and Nanotechnology 2015, 3, 1-2.
10. Evaluation of dose dependent cytotoxic effects of graphene oxide-iron oxide nanocomposite on Caprine Wharton’s Jelly derived mesenchymal stem cells, Gade, N.E., Dar ,.M. R., Mishra, O.P., Khan, J.R., Kumar V., Patyal, A. Journal of Animal Research 2015, 5, 415-421.
2014
9. Facile, rapid and upscaled synthesis of green luminescent functional graphene quantum dots for bioimaging, Kumar, V., Singh V, Umrao S., Parashar V., Abraham S., Singh A. K., Nath G., Saxena P. S., Srivastava A. RSC Advances 2014, 4, 21101-21107 (IF=4.02).
8. Nanostructured palladium-reduced graphene oxide platform for high sensitive, label free detection of a cancer biomarker, Kumar, V.,Srivastava, S., Umrao, S., Kumar, R., Nath, G., Sumana, G., Saxena, P. S., Srivastava, A. RSC Advances 2014, 4, 2267-2273 (IF=4.02).
7. Cefuroxime axetil loaded Solid Lipid Nanoparticles for enhanced activity against S. aureus biofilm, Singh, B., Vuddanda P. R., M. R Vijayakumar, Kumar, V., Saxena, P S., Singh, S. Colloids and Surfaces B: Biointerfaces 2014, 121, 92-98 (IF=5.99).
6. Synthesis of benzimidazole – grafted graphene oxide/multi-walled carbon nanotubes composite for supercapacitance application, Srivastava, R. K., Kumar V., Xingjue W., Srivastava A. Journal of alloys and compounds 2014, 612,343-348. (IF=6.37).
2013
5. Biofunctional magnetic nanotube probe for recognition and separation of specific bacteria from a mixed culture, Kumar, V., Nath, G., Kotnala, R. K., Saxena, P. S., Srivastava. A. RSC Advances 2013, 3, 14634-14641. (IF=4.02).
4. Electrophoretically deposited reduced graphene oxide platform for food toxin detection, Srivastava, S., Kumar, V., Ali, M. A., Solanki, P. R., Srivastava, A., Sumana, G., Saxena, P. S., Joshi, A.G., Malhotra, B. D. Nanoscale 2013, 5,3043-3051. (IF=8.30).
2011
3. Study of mechanism of enhanced antibacterial activity by green synthesis of silver nanoparticles. Parashar, U. K., Kumar, V., Bera, T., Saxena, P. S., Nath, G., Srivastava, S. K., Giri, R., Srivastava. A., Nanotechnology 2011, 22, 415104-415117. (IF=3.87)
2. Refinement of the optical properties by controlling the morphology of silver nanoparticles employing blended reducing agents. Parashar, U. K., Kumar, V., Saxena, P .S., Srivastava, A., Journal of Optoelectronics and Advanced Materials 2009, 11, 441-445.
1. Gold Nanoparticles supported on MoS2 Nanoribbons matrix as a biocompatible and water dispersible platform for enhanced photothermal ablation of cancerous cells using harmless near infrared irradiation irradiation Pandey, S., Kumar, V., Bansal A., Mishra, H., Kashyap, S., Srivastava, A., Saxena, P. S., arXiv.org > cond-mat > arXiv:1412.4943.
BOOK CHAPTERS:
1. Nanocomposite as Bone Implant Material, Kumar, V., Tripathi, B., Srivastava, A., Saxena, P. S. Springer Hand Book Nanomaterials, (ISBN:978-3-642-20594-1) 2013, 941-965
2. Functionalized nanosized graphene and its derivateives for removal of contamination and water treatment, Kumar, R. Singh, R., Kumar, V., Moshkalev, A. S., A New Generation Material Graphene: Applications in Water Technology, Springer International Publishing AG, Part of Springer Nature, (Online ISBN No: 978-3-319-75484-0), 2018, 133-185
3. Synthesis and Characterization of Phosphorene: A Novel 2D Material, Umrao, S. , Nirala, N. R., Khandelwal, G., Kumar, V.*, Nanomaterials: Biomedical and Environmental Applications, Scrivener Publishing, (Online ISBN No: 9781119370383), 2018, 61-83
4. Plasmonic Nanopores: A New Approach Toward Single Molecule Detection, Khandelwal, G., Umrao, S., Nirala, N. R., Sagar, S.S, Kumar, V. * Nanomaterials: Biomedical and Environmental Applications, Scrivener Publishing, (Online ISBN No: 9781119370383), 2018, 259-278
5. Catalytically Active Enzyme Mimetic Nanomaterials and Their Role in Biosensing, Nirala, N. R., Umrao, S., Khandelwal, G., Kumar, V.*, Nanomaterials: Biomedical and Environmental Applications, Scrivener Publishing , (Online ISBN No: 9781119370383), 2018, 285-296
6. Graphene-Based Electrochemical Sensors for Biomolecules, Kahndelwal, G., Sharma, K., Kumar, V.*, Graphene-Based Electrochemical Sensors for Biomolecules, Elsevier Publishing, (Online ISBN No: 9780128156391) 2018, 89-111
7. Antimicrobial activities of graphene polymer nanocomposites, Khandelwal, G., Kumar, R., Kumar, V*, Elsevier Publications (Online ISBN- 9780128168929), Nanostructured Polymer Composites for Biomedical Applications 2019, 429-445
(*Corresponding author)
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