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राष्ट्रीय पशु जैव प्रौद्योगिकी संस्थान
National Institute of Animal Biotechnology
An Autonomous Institute of the Department of Biotechnology,
Ministry of Science and Technology, Government of India
राष्ट्रीय पशु जैव प्रौद्योगिकी संस्थान
National Institute of Animal Biotechnology
An Autonomous Institute of the Department of Biotechnology,
Ministry of Science and Technology, Government of India
Dr G. Taru Sharma is a molecular reproductive biologist, with the major research emphasis on buffalo embryo genomics and stem cell therapeutics in livestock and pets, did her doctorate in 1989 from ICAR-IVRI with full fellowship support in animal physiology as a major discipline, animal biochemistry and animal reproduction as minor disciplines, PDF in 1999 from LSU, Baton Rouge, USA on somatic cell cloning using bovine IVF embryos.
Before joining DBT-NIAB, she was Principal Scientist and Head Physiology and Climatology Division, Director Centre for Advanced Faculty Training and Chairperson, faculty of Veterinary Physiology, at ICAR- IVRI, Izatnagar. During last 35 years of research and academic experience she did serve at the ICAR-Central institute for research on goats, Makhdoom, Center for Biotechnology, NDDB, Mumbai, mentored by Prof. KKG Menon at NDDB and Dr. Lalji Singh at CCMB, Hyderabad for buffalo embryo sexing. Research Scientist at Bio Med., a vaccine producing unit, established a Cell culture Lab of QC Unit.
Dr. Sharma has developed a novel, innovative and efficacious three-dimensional (3D) microenvironment model, developed efficient technique for buffalo female germplasm cryopreservation in indigenously developed cryo-device. Elucidated expression pattern profile and characterization of developmental important gene for in-vitro produced and in-vivo derived buffalo embryos. Documented, excellent studies on translational feasibility & application of adult/fetal stem cells, her group has made a dent to highlight the molecular and cellular characterization from the bone marrow derived stem cells of buffaloes, goat fetal adnexa derived stem cells authenticated by its therapeutic application, before and after cryopreservation. She has published more than 125 research papers of International repute and presented more than 200 papers at various National and International platform, visited 11 countries. She is Fellow NASI, NAAS, FAO and SAPI, has mentored more than a thirty M.V.Sc and Ph.D scholars, authored books/ book chapters, applied four patents. She is a member of important policy related committees at ICAR, DBT, CSIR and others. She is an EC member of NAAS and member of the Inter academia panel for women in STEMM. Dr. Sharma holds important positions in various scientific societies and she is the founder president of Animal Physiologists Association.
Awards
1. ICAR- RAFI AHMED KIDWAI AWARD-2018 (Highest research award of Indian Council of Agricultural Research, New Delhi)
2. G. P. Talwar Oration Gold Medal-2019
3. ICAR-Bharat Ratna Dr. C. Subramaniam Award for Outstanding Teachers- 2016.
4. Labhsetwar award by for the significant contributions in an area of Reproductive Physiology-2016
5. ICAR-IVRI Best Teacher Award-2013
6. Dr. A. Roy Memorial Award-2012
7. Award of honor by the Governor of U.P on World Veterinary Day, for successfully treated Canine spinal injuries, paraplegia, non-union fracture healing and wound repair through stem cell therapy-2011
8. DBT- NATIONAL BIOSCIENCE AWARD FOR CAREER DEVELOPMENT-2006
9. ICAR-Panjabrao Deshmukh Best Woman Agricultural Scientist Award-2004
10. WEAL award of ISIWCD-2003
11. Nils Lagerlof Memorial Award- 2001
12. Young scientists Merit certificate by Indian Science Congress Association-1994
13. Young scientist’s award and young scientist gold medal from SAPI-1993.
Research
Coordinating flagship program of DBT on creating host pathogen interaction platform at NIAB, entitled, “Genomics assisted pathobiology to identify novel targets for diagnosis and therapeutic intervention(s) of Japanese encephalitis and Leptospirosis”
1. G.Taru Sharma, Vikash Chandra, Pratheesh Mankuzhy, Yasotha Thirupathy, Dilip Swain, Harikrishna Pillai, Shailesh Kumar Patel, Mamta Pathak and SaiKumar Guttula (2021) Physiological Implications of COVID-19 in Reproduction: ACE2 a Key Player.Reproduction Fertility and Development.
2. Gutulla Taru Sharma, Amar Nath, Shiv Prasad, Sumit Singhal,Vikash Chandra Gutulla Saikumar (2020) Expression pattern of GLUT 1, 5, 8 and citrate synthase transcripts in buffalo (Bubalus bubalis) preimplantation embryos produced in vitro and derived in vivo.Reproduction in Domestic Animals. 55(10) doi; 10.1111/rda.13782. 55:1362-1376.
3. Sriti Pandey, I.A.Bhat, Mukesh. K.Bharti, Uffaq Shabir, Bilal Ahmad Peer, Indu Baiju, Vikash Chandra, G.Saikumar and G.Taru Sharma (2020) Progesterone modulates adhesion molecules in uterine epithelial cells and in vitro embryo production in buffalo. Reproduction in Domestic Animals. 55(7), 833-843 Doi; 10.1111/rda.13691.
4. Anand Joseph, Indu Baiju, Irfan A. Bhat, Sriti Pandey, Mukesh Bharti, Megha Verma, Anuj Pratap Singh, Matin M. Ansari, Vikash Chandra, G. Saikumar, Amarpal and G.Taru Sharma (2020) Mesenchymal Stem Cell-Conditioned Media: A Novel Alternative of Stem Cell Therapy for Quality Wound Healing. Journal of Cellular Physiology. DOI: 10.1002/jcp.29486. 235:5555–5569.
5. Mukesh K Bharti, Irfan A. Bhat, Sriti Pandey, Uffaq Shabi, Bilal A. Peer, B. Indu, Abas Rashid Bhat, G.SaiKumar, Amarpal , Vikash Chandra, G.Taru Sharma, (2020). Effect of cryopreservation on therapeutic potential of canine bone marrow derived mesenchymal stem cells augmented meshs scaffold for wound healing in guinea pig.Biomedicine&Pharmacotherapy,121,109573.https://doi.org/10.1016/j.biopha.2019.109573.
6. Irfan A. Bhat, Sivanarayanan T.B, Anjali Somal, Sriti PandeyMukesh B., BibudattaS.K.Panda, Indu B., MeghaVerma,Anand J., Arvind Sonwane, G.Saikumar, Amarpal, Vikash Chandra and G.Taru Sharma (2019) An allogenic therapeutic strategy for canine spinal cord injury using mesenchymal stem cells. Journal of Cellular Physiology. 234:2705–2718.
7. Swati Gupta, Sriti Pandey, Mehtab S. Parmar, Anjali Somal, Avishek Paul, Bibhudatta K. Panda, Irfan A. Bhat, Indu Baiju, Mihir Sarkar, Vikash Chandra and G.Taru Sharma (2017) Impact of oocyte-secreted factors on its developmental competence in buffalo. Zygote.25 (3):313-320.
8. Anjali Somal, Irfan A. Bhat, Indu B., Anuj Pratap Singh, Bibhudatta S. K. Panda, PerumalArumugamDesingu, Sriti Pandey, Mukesh Kumar Bharti, Amarpal, G. Saikumar, Vikash Chandra and G.Taru Sharma (2017). Impact of cryopreservation on caprine fetal adnexa derived stem cells and its evaluation for growth kinetics, phenotypic characterization and wound healing potential in xenogenic rat model. Journal of Cellular Physiology.232: 2186–2200.
9. Nitin E. Gade, Pratheesh M.D., Amar Nath, Amarpal, Pawan K. Dubey , Bhaskar Sharma, G. Saikumar and G.Taru Sharma (2013). Molecular and cellular characterization of buffalo bone marrow derived mesenchymal stem cells. Reproduction in Domestic Animals 48(3):358-367.
10. G.Taru Sharma, Pawan K. Dubey, Amar Nath, Prathessh MD. G. Sai Kumar (2012). Collagen-IV induces embryoid bodies formation and differentiation from buffalo (Bubalus bubalis) embryonic stem cells. Biochemical and Biophysical Research Communications 424, 378-384.
11. Om Prakash Verma, Rajesh Kumar, Amar Nath, Manjinder Sharma, Pawan K. Dubey, G. Sai Kumar and G.Taru Sharma (2012). In vivo differentiation potential of buffalo (Bubalus bubalis) embryonic stem cells. In Vitro Cellular and Developmental Biology-Animal 48 (6) Page 349-358.
12. Pawan K. Dubey, VrajeshTripathi, Ram Pratap Singh, G. Saikumar, Amar Nath, Pratheesh, M.D., Nitin Gade and G.Taru Sharma (2012). Expression of nitric oxide synthase isoforms in different stages of buffalo (Bubalus bubalis) ovarian follicles: effect of nitric oxide on in vitro development of preantral follicle. Theriogenology77; 280-291.
13. G.Taru Sharma, Pawan K. Dubey and Vikash Chandra (2010). Morphological changes, DNA damage and embryonic developmental competence of in vitro matured, vitrified-thawed buffalo (Bubalus bubalis) oocytes: A comparative study of two cryoprotectants and two cryodevices. Cryobiology 60: 315-321.
14. G.Taru Sharma Pawan K. Dubey and S.K.Meur (2009) Survival and developmental competence of buffalo pre antral follicles using three dimensional collagen gel culture system. Animal Reproduction Science 114; 115-124.
15. Sharma G Taru, Majumdar A C and Bonde S W. (1996). Chronology of maturational events in goat oocytes cultured in-vitro. Small Ruminant Research 22: 25 – 30.
1. Study on ultralow preservation of female germplasm and its use for in vitro embryo production in buffalo and goats. NATP-CGP World Bank, 2002- 2005.
2. Studies on in vivo and in vitro embryo generation in buffalo, ICAR, 2002- 2005
3. Cryopreservation of the buffalo oocytes, ICAR, 2005-2007
4. Isolation, characterization and in vitro development of buffalo preantral follicles for embryo production, DBT, 2006- 2009
5. Transfer of the in vitro derived buffalo embryos to surrogate dam, ICAR, 2007-2009
6. Expression of Developmental genes in Buffalo Oocytes, in vitro derived embryos and in Nuclear transfer embryos reconstructed with the embryonic stem cells, DBT, 2007-2011
7. Transcriptional level of developmentally important genes in buffalo pre implantation embryos, ICAR- World Bank NFBSRA, 2006-2013
8. Isolation, culture and Molecular Characterization of Rabbit Bone Marrow Derived Mesenchymal Stem Cells (MSCs), ICAR, 2010-2013
9. Ex-vivo expansion and characterization of mesenchymal stem cells for its therapeutic application, ICAR, 2011-2013.
10. Expression and localization of autocrine and paracrine factors and their receptors regulating corpus luteum function during the estrous cycle of buffaloes, DBT, 2011-2014.
11. Confirmation of lactation performance and animal safety of dairy animals of the Bos sp. treated with recombinant bovine somatotropin, ELANCO (Indo-US), 2012-2015 (Contract Research Project).
12. Understanding the basic mechanisms to improve buffalo embryo production, ICAR, 2013-2016.
13. Evaluation of bone marrow derived mesenchymal stem cells for peripheral nerve repair in rabbits, ICAR, 2013-2016
14. Therapeutic Potential of Caprine Bone Marrow Derived Mesenchymal Stem Cell Conditioned Media, UPCAR, 2014-2017
15. Application of nano-material on propagation and differentiation of animal stem cells for therapeutic applications., ICAR, 2014-2017
16. Stem Cells: Its Biology and Therapeutic Application in Livestock and Pets, ICAR Flagship project, 2015-2017
17. Study of oxidatively damaged proteins and the measures to reduce the protein damage due to cryopreservation in buffalo (Bubalus bubalis) semen, ICAR, 2017-2020
18. Bioactive meshes generation: An innovative exploration for its feasibility in stem cell therapeutic application, ICAR, 2017-2018
19. Unraveling the mechanism of embryo-uterine interaction for improvement of in vitro embryo production in buffalo, ICAR, 2018-2020
20. Development of stem cell laden nanomaterial scaffold for nerve, bone and cartilage tissue regeneration in animal, Niche Area of Excellence, 2018-2021.
21. Regulation of corpus luteum function by locally produced angiogenic growth factors in pigs (Susscrofa), DBT-NER, 2018-2021.
22. The effect of supplementation of emzymes associated in the repair of oxidatively damaged proteins on cryopreserved buffalo semen, DBT-Animal Biotechnology, 2018-2021
23. Generation of BMPR-IB gene edited goats using CRISPR/Cas technology to explore the functional role of BMPR-IB gene on goat reproduction, World Bank, 2019-2022
24. A chemical biology approach for early detection of pregnancy in buffaloes, DBT-Animal Biotechnology, 2019-2022.
25. All India Network Project on diagnostic imaging and management of surgical conditions in animals, World Bank, 2019-2022
26. Modulation of Wnt signaling pathway in mesenchymal stem cells for regulating the osteogenic differentiation in fracture model, ICAR, 2020-2023.
National Institute of Animal Biotechnology
Survey No. 37, Opp. Journalist Colony
Extended Q City Road, Near Gowlidoddy
Gachibowli, Hyderabad
Telangana – 500032
Email: tarusharma[at]niab[dot]org[dot]in
Tel: +91-(0)40-2312-0101/102
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