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राष्ट्रीय पशु जैव प्रौद्योगिकी संस्थान
National Institute of Animal Biotechnology
An Autonomous Institute of the Department of Biotechnology,
Ministry of Science and Technology, Government of India
राष्ट्रीय पशु जैव प्रौद्योगिकी संस्थान
National Institute of Animal Biotechnology
An Autonomous Institute of the Department of Biotechnology,
Ministry of Science and Technology, Government of India
Dr. Subeer S. Majumdar has done his M.Sc. from Nagpur University and did his Ph.D. work at National Institute of Health & Family Welfare, New Delhi, India. He did his Postdoctoral Research at School of Medicine, Southern Illinois University, Carbondale, USA and at Department of Cell Biology and Physiology, University of Pittsburgh, USA. He was working at National Institute of Immunology, New Delhi prior to assuming this responsibility.
Fellowships of Science Academics:
1. Fellow: The National Academy of Sciences, 2009
2. Fellow: Indian National Science Academy, 2009
3. Fellow: Indian Academy of Sciences, 2014
Awards:
1. Bob Edward Oration Award for Studies of Functional Genomics, To Decipher New Factors which may Aid to generate Fertile Sperm, In cases of Idiopathic Male infertility at 8th International congress of ACE (July, 2019)
2. The J.C. Bose Fellowship (March 2018)
3.Manipal Association of Clinical Embryologists (MACE) Award 2016 for outstanding contribution to embryology (March 2017)
4. Dr. NN Dastur Memorial Oration award awared during NDRI’s Academic Week celebrations (February 2017).
5. Dr. T. C. Anandkumar Gold Medal Oration award of Indian society for study of Reproduction and Fertility, (Feb, 2014)
6. Richard Masillamony Gold medal oration award, given by Indian Society for Veterinary immunology and Biotechnology, (2013).
7. P. Govindarajalu Gold medal oration award for Reproductive sciences by Society of Reproductive Biology and Cellular Endocrinology (2012).
8. TATA INNOVATION Fellowship, Given by DBT for application oriented innovative research carried in India, (2011).
9. National Academy of Science – Reliance Industries platinum Jubilee award for application oriented innovations in biological sciences, (2011).
10. Labshetwar Award, Given by the Indian Society for study of Reproduction and fertility for population control, (2007).
11. Fellow, The Lalor Foundation, USA, Southern Illinois Univ, 1989-1990
12. Fellow: AW Mellon Foundation, USA, Univ. of Pittsburgh, 1991-1994
Membership of Professional Societies:
1. Member, the Endocrine Society, USA
2. Member, Society for the Study of Reproduction, USA
Dr. Majumdar’s lab works in the field of animal biotechnology, genomics and animal reproduction. His present research focus lies in the field of…
1. Production of therapeutic proteins for animal and human in the milk of farmed animals.
2. New Methods of transgenesis for biomedical research including generation of transgenic animals for mimicking pathophysiological conditions of human and animal disaeses. Aiming transgenesis to facilitate production of transgenic cattle, goat for increasing quality of herd, making disease resistant and more milk yielding animals.
3. Livestock genomics and SNP vhip development for herd improvement.
4. Alternative to knock out technology, utilizing shRNA to generate transgenic animals.
5. Coordinating and PI in One Health consortium initiative of India.
6. Coordinating and PI in Societal Development, Project on enhancing socio economic satatus of farmers of aspirational district of Yadagir, at karnataka.
7. Coordinating flagship program of DBT on creating host pathogen interaction platform at NIAB (using JEV and Leptospira).
8. Coordinating National Academy of Sciences and DST’s program on uplifting of ST farmers via NIAB.
Some of the best Publications:
1. Indrashis Bhattacharya, Sayon Basu, Bhola Shankar Pradhan, Hironmoy Sarkar, Perumal Nagarajan, Subeer S Majumdar. Testosterone augments FSH signaling by upregulating the expression and activity of FSH-Receptor in Pubertal Primate Sertoli cells. Molecular and cellular endocrinology, 2019, 482, 70-80
2. Souvik Sen Sharma, Subeer S. Majumdar. Transcriptional co-activator YAP regulates cAMP signaling in Sertoli cells. Molecular and Cellular Endicrinology, 2017, Volume 450, 15 July 2017, Pages 64–73, https://doi.org/10.1016/j.mce.2017.04.017
3. Kamal Mandal, Samue L. Bader, Pankaj Kumar, Dipankar Malakar, David S. Campbel, Bhola Shankar Pradhan, Rajesh K. Sarkar, Neerja Wadhwa, Souvik Sensharma, Vaibhav Jain, Robert L. Moritz, and Subeer S. Majumdar. An integrated transcriptomics-guided genomewide promoter analysis and next-generation proteomics approach to mine factor(s) regulating cellular differentiation. DNA Research, 2017, doi: 10.1093/dnares/dsw057
4. Abul Usmani, Nirmalya Ganguli, Subodh K Jain, Nilanjana Ganguli, Rajesh Kumar Sarkar, Mayank Choubey, Mansi Shukla, Hironmoy Sarkar and Subeer S Majumdar. Robust generation of transgenic mice by simple hypotonic solution mediated delivery of transgene in testicular germ cells. Molecular Therapy- Methods & Clinical Development, 2016, 3, 16076; doi:10.1038/mtm. 2016.76
5. Nirmalya Ganguli, Neerja Wadhwa, Abul Usmani, Neetu Kunj, Nilanjana Ganguli, Rajesh Kumar Sarkar, Soma M Ghorai, Subeer S Majumdar. An efficient method for generating a germ cell depleted animal model for studies related to spermatogonial stem cell transplantation. Stem Cell Research and Therapy, 2016, 7: 142. doi:10.1186/s13287-016-0405-1
6. Bhola Shankar Pradhan and Subeer S. Majumdar. An efficient method for generation of transgenic rats avoiding embryo manipulation. Molecular Therapy-Nucleic Acid, 2016 Mar; 5(3): e293. Published online 2016 Mar 8. doi: 10.1038/mtna.2016.9
7. Nirmalya Ganguli, Nilanjana Ganguli, Abul Usmani and Subeer S. Majumdar. Isolation and functional characterization of buffalo (Bubalus bubalis) ß-casein promoter for driving mammary epithelial cell-specific gene expression. Journal of Biotechnology, 2015, 198, 53-59,2015
8. Indrashis Bhattacharya, Sayon Basu, Kanchan Sarda, Mukkesh Gautam, Perumal Nagarajan, Bhola Shankar Pradhan, Hironmoy Sarkar, Yendrembam Sangeeta Devi and Subeer S. Majumdar. Low Levels of Gs and Ric8b in Testicular Sertoli Cells May Underlie Restricted FSH Action During Infancy in Primates. Endocrinology, 2015; 156 (3), 1143-1155
9. Usmani A, Ganguli N, Sarkar H, Dhup S, Batta SR, Vimal M, Ganguli N, Basu S, Nagarajan P, Majumdar SS. A non-surgical approach for male germ cell mediated gene transmission through transgenesis. Scientific Reports, 2013, 3:3430. doi: 10.1038/srep03430
10. Subeer S Majumdar, Kanchan Sarda, Indrashis Bhattacharya and Tony M Plant. Insufficient androgen and FSH signaling may be responsible for the azoospermia of the infantile primate testes that is exposed to an adult-like hormonal milieu. Human Reproduction, 2012, 27(8): 2515–2525
11. Durba Pal, Suman Dasgupta, Rakesh Kundu, Sudipta Maitra, Gobardhan Das, Satinath Mukhopadhyay, Sukanta Ray, Subeer S Majumdar & Samir Bhattacharya. Fetuin-A acts as an endogenous ligand of TLR4 to promote lipid-induced insulin resistance. Nature Medicine, 2012, 18(8):1279-1285
12. Suveera Dhup and Subeer S. Majumdar. Transgenesis via permanent integration of genes in repopulating spermatogonial cells in vivo. Nature Methods, 2008 5(7):601-603
13. Subeer S. Majumdar, Suveera Dhup and Abu-ul Usmani. Deathless transgenesis: A new spermatogonia mediated in vivo approach for generation of transgenic mice. Nature Protocols, 2008, DOI: 10.1038/nprot.2008.124
For complete list of publications, see Google Scholar Profile:
https://scholar.google.com/citations?hl=en&user=OOdXrM8AAAAJ
PhD Students:
Neelam Topno
Abhishek Das
Goutam Ulgekar
Venkateswaran Ganeshan
Project Associates – I:
Amit Pal
Satarupa Dutta
Dhirendra Suthar
Ongoing:
1. Genomics for conservation for indigenous cattle breeds and for enhancing milk yield, Phase-I.
2. Genome editing for generating semen favoring production of cow.
3. An attempt to generate transgenic pig through testicular transgenesis or male germ cell transplantation to enhance productivity.
4. Targeted sorting of transgenic sperm for enhancing adaptability of testicular transgenesis.
5. Feasibility of producing cattle gonadotropins in milk of rabbit by invivo gene transfection.
Forth Coming:
1. Therapeutic protein production in milk of farm animals to increase their affordability.
National Institute of Animal Biotechnology
Survey No. 37, Opp. Journalist Colony
Extended Q City Road, Near Gowlidoddy
Gachibowli, Hyderabad
Telangana – 500032
Email: subeer[at]niab[dot]org[dot]in
Tel: +91 40 2312 0175
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