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राष्ट्रीय पशु जैव प्रौद्योगिकी संस्थान
National Institute of Animal Biotechnology
An Autonomous Institute of the Department of Biotechnology,
Ministry of Science and Technology, Government of India
राष्ट्रीय पशु जैव प्रौद्योगिकी संस्थान
National Institute of Animal Biotechnology
An Autonomous Institute of the Department of Biotechnology,
Ministry of Science and Technology, Government of India
Dr. Madhuri Subbiah, graduated with Veterinary degree from Madras Veterinary College in 2005 and obtained her Ph.D. in Molecular Virology in 2010 from Dr. Siba K. Samal’s laboratory at the Department of Veterinary Medicine, University of Maryland, College Park, Maryland, USA. Between 2010 and 2012, she worked at Anthem Biosciences Pvt. Ltd., in Bangalore as Deputy Manager in Platform Technologies Division, Department of Discovery Biology, where she was involved in generating high-throughput mammalian cell-based platforms for drug and toxin screening. Since Nov 2012, she is serving as Scientist at the National Institute of Animal Biotechnology (NIAB), Hyderabad. Currently she is Scientist-E with research focus on economically important livestock and poultry viruses aiming at unravelling the molecular mechanisms behind the pathogenicity which could be potential used as strategies to combat the viral diseases.
Animal diseases affect livestock production both directly (mortality and morbidity and loss in productivity) and indirectly (cost incurred for the prevention and control measures). Thus, the major threat to our livestock farming and poultry industry is from infectious diseases and about 50% of these diseases are caused by viruses. Studying the animal viruses is not only essential for veterinary sciences but also for medical sciences considering the fact that 60% of all human infectious diseases recognized so far, and about 75% of emerging infectious diseases that have affected people over the past three decades, have originated from animals.
Dr. Subbiah’s work bridges fundamental virology and applied animal health—addressing emerging viral threats in poultry, livestock, and zoonotic pathogens with global implications for food safety and pandemic preparedness. Her research focus thrives on an integrated animal virology laboratory at NIAB with three prolonged approaches: (i) Viral assay biology for developing rapid on farm diagnostics and high throughput antiviral screens (ii) Viral epidemiology and molecular biology to understand and record the circulating/emerging viral strains in India and (iii) Viral biologicals to develop novel, safe and effective next generation vaccines and identification of effective antivirals.
Through active collaborations with researchers from state universities (TANUVAS, PVNRTVU) and national institutes (CAU, ICAR-DPR), her laboratory has reported these till date: A novel subgenotype of NDV circulating in India amongst vaccinated flocks (PMID: 30281910), new porcine circovirus-2 genotypes circulating in India (PMID: 33618002), the first complete genome sequence of Chicken Infectious Anemia virus (CAV) in India (PMID: 34861312), the first complete genome sequence of Lumpy Skin Disease virus in India (PMID: 36689139) and the first complete genome sequence of Duck Hepatitis A genotype 2 virus in India (PMID: 39798824).
The laboratory is also undertaking basic research to study viral biology and the mechanisms that can help us to prepare for and to respond to emerging viral threats. In collaboration with the Pennsylvania State University, USA, her laboratory has published their work on profiling of the sialic acid receptor of Emu to understand the role of Emu in evolution of Influenza A viruses (PMID: 27816637). The laboratory has also characterized the accessory viral proteins, V and W, of Newcastle disease virus that provide clues to understanding the viral pathogenesis and replication (PMIDs: 32533018, 37408548, 40290766).
With interest in therapeutics, more specifically platforms that can accelerate the antiviral drug discovery, the laboratory is developing in vitro reporter based screens mimicking different stages of virus infection to identify potent viral inhibitors.
1. Malwade RR, Mondal S, Ravindran Y, Venkataraman S, Rajkhowa T, Subbiah M. A recombinant HiBiT-tagged porcine circovirus type 2 (PCV2) reporter system identifies potent antiviral activity of terameprocol. Virology. 2026 Jun; 619:110885. doi: 10.1016/j.virol.2026.110885.
https://www.sciencedirect.com/science/article/pii/S0042682226001005
2. Malwade RR, Priyadharshini KM, Venkataraman S, Akakpo CO, Subbiah M. Diversity of porcine circovirus 2 genotypes: insights from the studies reported worldwide in the past decade. Virus disease. 2025 Dec;36(4):533-548. doi: 10.1007/s13337-025-00947-5.
https://link.springer.com/article/10.1007/s13337-025-00947-5
3. Deval S, Nathan VS, Venkataraman S, Rao PL, Kar PP, Srivastava A, Subbiah M. Accessory viral protein, V, of Newcastle Disease Virus binds dsRNA to facilitate immune evasion. Virus disease. Mar;36(1):68-80,2025.
https://link.springer.com/article/10.1007/s13337-024-00908-4
4. Rajendran R, Sundaram RS, Rao PL, Senthil Nathan DJ, Muthukrishnan M, Manoharan S, Srinivasan J, Balakrishnan G, Soundararajan C, Subbiah M. Molecular and phylogenetic analyses of the first complete genome sequence of Duck hepatitis A virus genotype 2 from India. Gene. Mar 15; 941:149236, 2025.
https://www.sciencedirect.com/science/article/pii/S0378111925000241?via%3Dihub
5. Nayak BN, Palanisamy P, Venkataraman S, Subbiah M. A time series transcriptome profiling of host cell responses to Newcastle disease virus infection. Archives of Virology. Aug 8;169(9):175, 2024.
https://link.springer.com/article/10.1007/s00705-024-06100-9
6. Rajendran R, Srinivasan J, Natarajan J, Govindan K, Kumaragurubaran K, Muthukrishnan M, Seeralan M, Subbiah M, Sundaram RS, Rao PL, Ramasamy S. First report of Duck Hepatitis A virus genotype 2 in India. Veterinary Research Communications. Sep;47(3):1231-1241, 2023.
https://link.springer.com/article/10.1007/s11259-022-10063-0
7. Nayak BN, Rajagopal K, Shunmugasundaram R, Rao PL, Vaidyanathan S, Subbiah M. Molecular characterization suggests kinetic modulation of expression of accessory viral protein, W, in Newcastle disease virus infected DF1 cells. Virus disease. Jun;34(2):236-247, 2023.
https://link.springer.com/article/10.1007/s13337-023-00813-2
8. Putty K, Rao PL, Ganji VK, Dutta D, Mondal S, Hegde NR, Srivastava A, Subbiah M. First complete genome sequence of lumpy skin disease virus directly from a clinical sample in South India. Virus Genes. Apr;59(2):317-322, 2023.
https://link.springer.com/article/10.1007/s11262-023-01967-3
9. Yenuganti VR, Afroz S, Khan RA, Bharadwaj C, Nabariya DK, Nayak N, Subbiah M, Chintala K, Banerjee S, Reddanna P, Khan N. Milk exosomes elicit a potent anti-viral activity against dengue virus. Journal of Nanobiotechnology. Jul 6;20(1):317, 2022.
https://jnanobiotechnology.biomedcentral.com/articles/10.1186/s12951-022-01496-5
10. Rao PL, Priyanka E, Kannaki TR, Subbiah M. Whole genome analysis and molecular characterization of chicken infectious anemia virus from an outbreak in a layer flock reveals circulation of genogroup IIIb in South India. Virus Research. Jan 15; 308:198649, 2022.
https://www.sciencedirect.com/science/article/pii/S0168170221003567?via%3Dihub
11. T. R. Kannaki, E. Priyanka, Y. Nishitha, S. Vamshi Krishna, Santosh Haunshi, Madhuri Subbiah. Molecular detection and phylogenetic analysis of Marek’s disease virus virulence-associated genes from vaccinated flocks in southern India reveals circulation of virulent MDV genotype. Transboundary and Emerging diseases. Jul;69(4):e244-e253, 2022.
https://onlinelibrary.wiley.com/doi/10.1111/tbed.14289
12. Tridib Kumar Rajkhowa, Lalnunthanga Lalnunthanga, Lalthapui Hauhnar, Doris Zodinpui, Madhuri Subbiah. Molecular detection and characterization of highly pathogenic porcine reproductive and respiratory syndrome virus from a natural outbreak in wild pigs, Mizoram, India. Transboundary and Emerging diseases. Jul;69(4):e288-e298, 2022.
https://onlinelibrary.wiley.com/doi/10.1111/tbed.14296
13. T.K. Rajkhowa, P.Lalnunthanga, P.L.Rao, M.Subbiah**, B.Lalrohlua. Emergence of porcine circovirus 2g (PCV2g) and evidence for recombination between genotypes 2g, 2b and 2d among field isolates from non-vaccinated pigs in Mizoram, India. Infection, Genetics and Evolution. Volume 90, 104775, 2021.
https://www.sciencedirect.com/science/article/pii/S1567134821000721?via%3Dihub
14. T. R. Kannaki, E. Priyanka, Madhuri Subbiah, Santosh Haunshi. Development and validation of high throughput Real-time Polymerase chain reaction assay for quantitative detection of Chicken Infectious Anemia Virus. Virus Disease. 32, pages343–346, 2021.
https://link.springer.com/article/10.1007/s13337-020-00648-1
15. G. Mahalakshmi & B. Selvakumar & K.N. Vennila & P. Lakshmana Rao & S. Madhuri & M. Seenivasaperumal & Kuppanagounder P. Elango. Spectroscopic Studies on the Interaction of Naphthyridines with DNA and Fluorescent Detection of DNA in Agarose Gel. Journal of Fluorescence. 31, pages327–338, 2021.
https://link.springer.com/article/10.1007/s10895-020-02658-0
16. K. N. Vennila, B. Selvakumar, V. Satish, D. Sunny, S. Madhuri, K. P. Elango. Structure-based design, synthesis, biological evaluation, and molecular docking of novel 10-methoxy dibenzo[b,h][1,6] naphthyridinecarboxamides. Medicinal Chemistry Research. 30, pages133–141, 2021.
https://link.springer.com/article/10.1007/s00044-020-02645-x
17. T. R. Kannaki, E. Priyanka, Santosh Haunshi and Madhuri Subbiah. A systematic review and meta-analysis on global prevalence of infectious diseases in backyard chicken in the recent two decades. Indian Journal of Poultry Science. 56 (3) 287-294, 2021.
https://www.researchsquare.com/article/rs-778051/v1
18. Cherukupalle Bhuvaneswar, Aluru Rammohan, Baki Vijaya Bhaskar, Pappithi Ramesh Babu, Gujjar Naveen, Duvvuru Gunasekar, Subbiah Madhuri**, Pallu Reddanna and Wudayagiri Rajendra. Sophora interrupta Bedd root derived flavonoids as prominent antiviral agents against Newcastle Disease Virus. RSC Adv., 10, 33534, 2020.
https://pubs.rsc.org/en/content/articlehtml/2020/ra/d0ra01820a
19. Pachineella Lakshmana Rao, Ravi Kumar Gandham & Madhuri Subbiah*. Molecular evolution and genetic variations of V and W proteins derived by RNA editing in Avian Paramyxoviruses. Scientific Reports. Volume 10, Article number: 9532, 2020.
https://pmc.ncbi.nlm.nih.gov/articles/PMC7293227/
20. Mahalakshmi, G., Vennila, K. N., Selvakumar, B., Rao, P. L., Malwade, R., Deval, S. Subbiah M., Srinivasaperumal, M & Elango, K. P. Spectroscopic investigations on DNA binding profile of two new naphthyridine carboxamides and their application as turn-on fluorescent DNA staining probes. Journal of Biomolecular Structure and Dynamics, 38(12), 3443–3451, 2019.
https://pubmed.ncbi.nlm.nih.gov/31422749/
21. Vennila, K.N., Prabha, K., Sunny, D. Subbiah, M. & K.P. Elango. Preparation and biological evaluation of quinoline amines as anticancer agents and its molecular docking. Med Chem Res 28, 1298–1307, 2019.
22. Gowtham V, Ganesan V, Gopala Krishna Murthy TR, Nair S, Yegavinti N, Saraswathy PV, Suresh Kumar G, Udhayavel S, Senthilvel K, Subbiah M. Molecular Phylogenetics of Newcastle disease viruses isolated from vaccinated flocks during outbreaks in Southern India reveals circulation of a novel sub-genotype. Transboundary and Emerging diseases. 66(1): 363-372, 2019.
https://onlinelibrary.wiley.com/doi/10.1111/tbed.13030
23. Selvakumar, B., Gujjar, N., Subbiah, M. et al. Synthesis and antiviral study of 4-(7,7-dimethyl-4-(piperazin-1-yl)-5,6,7,8-tetrahydroquinazolin-2-yl) morpholine derivatives. Med Chem Res 27, 512–519, 2018.
https://link.springer.com/article/10.1007/s00044-019-02374-w
24. Selvakumar Balaraman, Nagaraj Nayak, Madhuri Subbiah and Kuppanagounder P. Elango. Synthesis and antiviral study of novel 4-(2-(6-amino-4-oxo-4,5- dihydro-1H-pyrrolo[2,3-d]pyrimidin-3-yl)ethyl)benzamide derivatives. Medicinal Chemistry Research. 27, pages 2538–2546, 2018.
https://link.springer.com/article/10.1007/s00044-018-2256-z
25. Vennila KN, Sunny D, Madhuri S, Ciattini S, Chelazzi L, Elango KP. Design, synthesis, crystal structures and anticancer activity of 4-substituted quinolines to target PDK1. Bioorg Chem. 81:184-190, 2018.
https://www.sciencedirect.com/science/article/pii/S0045206818305789?via%3Dihub
26. Balaraman Selvakumara, Saraswathy P. Vaidyanathan, Subbiah Madhuri and Kuppanagounder P. Elango. Synthesis and antiviral activity of sulfonohydrazide and 1,3,4-oxadiazole derivatives of 6,6-dimethyl-9-oxo-4,5,6,7,8,9-hexahydropyrazolo[5,1-b] quinazoline. Journal of Chemical Research, 41 (4), 221-224, 2017.
https://link.springer.com/article/10.1007/s00044-018-2256-z
27. Balaraman Selvakumar, S. P. Vaidyanathan, Madhuri Subbiah and Kuppanagounder P. Elango. Synthesis and antiviral activity of 4-(7,7-dimethyl-4-[4-{N-aroyl/benzyl}1- piperazinyl]-5,6,7,8-tetrahydroquinazolin-2-yl)morpholine derivatives. Arkivoc, part iv, 353-364, 2017.
http://niab.sciencecentral.in/59/
28. Naveen Gujjar, Shubhada K. Chothe, Shashikant Gawai, Ruth Nissly, Gitanjali Bhushan, Vijayarani Kanagaraj, Bhushan M. Jayarao, Kumanan Kathaperumal, Madhuri Subbiah** and Suresh V. Kuchipudi. Co-expression of sialic acid receptors compatible with avian and human influenza virus binding in emus (Dromaius novaehollandiae). Virology 500: 14-121, 2017.
https://www.sciencedirect.com/science/article/pii/S0042682216303336?via%3Dihub
29. SP Vaidyanathan, S Gawai, M Subbiah. Elucidation of the role of non-structural viral protein (W) of Newcastle disease virus. International Journal of Infectious Diseases 45: 337-338, 2016.
https://www.ijidonline.com/article/S1201-9712(16)30709-3/fulltext
30. Karnati HK, Pasupuleti SR, Kandi R, Undi RB, Sahu I, Kannaki TR, Subbiah M, Gutti RK. TLR-4 signalling pathway: MyD88 independent pathway up-regulation in chicken breeds upon LPS treatment. Vet Res Commun. Mar; 39(1):73-8, 2015.
https://link.springer.com/article/10.1007/s11259-014-9621-2
31. Rajakrishna L, Krishnan Unni S, Subbiah M, Sadagopan S, Nair AR, Chandrappa R, Sambasivam G, Sukumaran SK. Validation of a human cell based high-throughput genotoxicity assay ‘Anthem’s Genotoxicity screen’ using ECVAM recommended lists of genotoxic and non-genotoxic chemicals. Toxicol In Vitro. Feb; 28 (1): 46-53, 2014.
https://www.sciencedirect.com/science/article/pii/S0887233313001793?via%3Dihub
32. Xiao S, Khattar SK, Subbiah M, Collins PL and Samal SK. Mutation of the F protein cleavage site of avian paramyxovirus-7 results in furin cleavage, fusion promotion and increased replication in vitro, but not increased replication, tissue tropism, or virulence in chickens. Journal of Virology. Jan; 86(7): 3828-3838, 2012.
https://journals.asm.org/doi/full/10.1128/jvi.06765-11
33. Kim SH, Subbiah M, Samuel AS, Collins PL and Samal SK. Roles of the fusion and hemagglutinin-neuraminidase proteins in replication, tropism, and pathogenicity of avian paramyxoviruses. Journal of Virology. Sep;85(17):8582-8596, 2011.
https://pmc.ncbi.nlm.nih.gov/articles/PMC3165810/
34. Subbiah M, Khattar SK, Collins PL and Samal SK. Mutations in the fusion protein cleavage site of avian paramyxovirus serotype 2 increase cleavability and syncytium formation but do not increase viral virulence in chickens. Journal of Virology. Jun;85(11):5394-5405, 2011.
https://pmc.ncbi.nlm.nih.gov/articles/PMC3094964/
35. Samuel AS, Subbiah M, Shive H, Collins PL and Samal SK. Experimental infection of hamsters with avian paramyxovirus serotypes 1 to 9. Veterinary Research. Feb;42(1):38, 2011.
https://pmc.ncbi.nlm.nih.gov/articles/PMC3052182/
36. Subbiah M, Xiao S, Khattar SK, Dias FM, Collins PL, Samal SK. Pathogenesis of two strains of avian paramyxovirus serotype 2, Yucaipa and Bangor, in chickens and turkeys. Avian Diseases. Sep;54(3):1050-7, 2010.
https://pmc.ncbi.nlm.nih.gov/articles/PMC3428046/
37. Subbiah M, Nayak S, Collins PL, Samal SK. Complete genome sequences of avian paramyxovirus serotype 2 (APMV-2) strains Bangor, England and Kenya: evidence for the existence of subgroups within serotype 2. Virus Research. Sep;152(1-2):85-95, 2010.
https://pmc.ncbi.nlm.nih.gov/articles/PMC2914170/
38. Xiao S, Subbiah M, Kumar S, De Nardi R, Terregino C, Collins PL, Samal SK. Complete genome sequences of avian paramyxovirus serotype 6 prototype strain Hong Kong and a recent novel strain from Italy: evidence for the existence of subgroups within the serotype. Virus Research. Jun;150(1-2):61-72, 2010.
https://pmc.ncbi.nlm.nih.gov/articles/PMC2914170/
39. Samuel AS, Kumar S, Madhuri S, Collins PL, Samal SK. Complete sequence of the genome of avian paramyxovirus type 9 and comparison with other paramyxoviruses. Virus Research. Jun;142(1-2):10-8, 2009.
https://pmc.ncbi.nlm.nih.gov/articles/PMC2782688/
40. Paldurai A, Subbiah M, Kumar S, Collins PL, Samal SK. Complete genome sequences of avian paramyxovirus type 8 strains goose/Delaware/1053/76 and pintail/Wakuya/20/78. Virus Research. Jun;142(1-2):144-53, 2009.
https://pmc.ncbi.nlm.nih.gov/articles/PMC2782673/
41. Xiao S, Paldurai A, Nayak B, Subbiah M, Collins PL, Samal SK. Complete genome sequence of avian paramyxovirus type 7 (strain Tennessee) and comparison with other paramyxoviruses. Virus Research. Oct;145(1):80-91, 2009.
https://pmc.ncbi.nlm.nih.gov/articles/PMC3292215/
42. Subbiah M, Xiao S, Collins PL, Samal SK. Complete sequence of the genome of avian paramyxovirus type 2 (strain Yucaipa) and comparison with other paramyxoviruses. Virus Res. Oct;137(1):40-8, 2008.
https://pmc.ncbi.nlm.nih.gov/articles/PMC2700353/
43. Subbiah M, Yan Y, Rockemann D, Samal SK. Experimental infection of calves with Newcastle disease virus induces systemic and mucosal antibody responses. Arch Virol.;153(6):1197-200, 2008.
https://link.springer.com/article/10.1007/s00705-008-0099-5
PATENTS:
International patent:
1. Identification of Cellulolytic Microorganism Contamination in Food and other Materials (International Application No.: WO2013140210A1).
2. An in Vitro Method for High Throughput Screening of Genotoxic Agents in Eukaryotic Cells (International Application No.: US20140148360A1).
Indian patent filed:
1. Methods for Detecting Viral Protein and Antiviral Compounds thereof (Application No. 4065/CHE/2011).
2. Accessory Viral Protein as Anticancer Agent (Application no. 202141006360), dated 14-02-2022.
3. Method for Producing Increased Yield of Recombinant Nucleocapsid Protein of Porcine Reproductive and Respiratory Syndrome Virus. (Application No. 202411091860), dated 25-11-2024.
Ruchi Malwade
Research Interest: Recombinant Chimeric Porcine Circovirus as a potential Multivalent Vaccine Vector.
https://pubmed.ncbi.nlm.nih.gov/41426358/
https://pubmed.ncbi.nlm.nih.gov/41894906/
PhD thesis submitted, currently employed as Senior Executive as VIRBAC, Hyderabad, India
Subhajit Mondal| SPA
Research Interest: Development of a reverse genetics-based, BSL-2 compatible surrogate assay system to enable antiviral screening and replication studies for Nipah virus.
Tanmay Jana| SRF-UGC
Research Interest: Exploration of Chicken Innate Immune response to Newcastle disease virus to understanding host immune response to Newcastle disease virus infection in chickens.
Christophert Akakpo| TWAS-DBT Postgraduate Fellow from Benin Republic (MSc in Vaccine Production and QC from Pan-Africaine University of Ibadan, Nigeria)
Research Interest: Development of serological diagnostic kit based on a chimeric antigen of Chicken Infectious Anemia Virus and exploration of a mucosal VLP vaccine platform using natural gum.
Akanksha Verma| JRF-UGC
Research Interest: Improved vaccine against NDV
Dr. Lakshmana P Rao
PhD thesis title: Improving viral gene expression using twin technologies: replication-defective adenovirus & reverse genetics to study NDV viral biology and protein function.
https://www.nature.com/articles/s41598-020-66252-x
https://www.sciencedirect.com/science/article/pii/S0168170221003567?via%3Dihub
https://link.springer.com/article/10.1007/s11262-023-01967-3
Dr. Sunny Deval
PhD thesis title: Accessory viral protein, V, of Newcastle Disease Virus binds dsRNA to facilitate immune evasion.
https://link.springer.com/article/10.1007/s13337-024-00908-4
Dr. Nagaraj B Nayak
PhD thesis title: Molecular characterization suggests kinetic modulation of expression of accessory viral protein, W, in Newcastle disease virus infected DF1 cells.
https://link.springer.com/article/10.1007/s13337-023-00813-2
https://link.springer.com/article/10.1007/s00705-024-06100-9
Currently employed as Senior Biocurator at Velsera, India
Dr. Bhuvan Cherukupalle
PhD fellow from SV University, Tirupati who did his Virology work at NIAB
PhD thesis title: Sophora interrupta Bedd, root-derived flavonoids as prominent antiviral agents against Newcastle disease virus.
https://pubs.rsc.org/en/content/articlelanding/2020/ra/d0ra01820a
Industrial Project:
1. As PI: Genotyping of Newcastle Disease Virus Strains: Biological and Molecular Characterization. Funding by Globion Pvt. Ltd., Hyderabad, India. 2015-2017 (12 lakhs, 1 Project fellow for 1 yr and 3 months)
National Projects:
1. As Non-NER PI, DBT-NER Twinning: A study to understand the genetic variations among the field isolates of porcine circo viruses from piggery farms in Mizoram, with ultimate aim to develop rapid diagnostics for earlier detection of the viruses, differentiation of vaccinated and infected animals and to engineer an effective recombinant chimeric DIVA vaccine. 2016-2020 (DBT-NER Twinning)- completed.
2. As PI, DBT Taskforce: Elucidation of the Role of Non-structural (W) Protein of Avian Paramyxoviruses. 2015-2018 (DBT taskforce) –completed.
3. As PI of Non-NER, DBT Network program on ‘Molecular platform for epidemiology, disease mapping and development of diagnostics for economically important diseases of ducks’. 2018-2021 (DBT-NER Duck program) –completed.
4. As CCPI, ICAR NASF on ‘Molecular biological studies on porcine reproductive & respiratory syndrome (PRRS) virus in pig population of North East Region of India for development of sustainable diagnostics and vaccine’. 2020-2023 (ICAR-NASF) – completed.
International Projects:
1. BBSRC India Partnering Award ‘Collaboration on Diagnosis of Emerging Viruses’. 2014-2018. In collaboration with University of Nottingham, UK and TANUVAS, India – completed.
2. BBSRC India Partnering Award ‘Understanding the emergence of variant infectious bronchitis virus in chickens in UK and India: shared control strategies’. 2017-2021. In collaboration with University of Liverpool, UK and TANUVAS, India – completed.
NIAB Core funded Projects:
1. PI – Establishment of system for engineering recombinant NDV – completed.
2. PI – Understanding the upstream mechanism leading to enhanced replication of NDV by its V protein – completed.
National Institute of Animal Biotechnology
Survey No. 37, Opp. Journalist Colony
Extended Q City Road, Near Gowlidoddy
Gachibowli, Hyderabad
Telangana – 500032
Email: madhuri[at]niab[dot]org[dot]in
Tel: +91-(0)40-2312-0143
Pubmed Link
Animal Viral Diseases Laboratory at BRIC-NIAB has reported the below in active collaboration with researchers across India:
(a) A novel subgenotype of NDV circulating in India amongst vaccinated flocks (PMID: 30281910),
(b) New porcine circovirus-2 genotypes circulating in India (PMID: 33618002),
(c) First complete genome sequence of Chicken Infectious Anemia virus (CAV) in India (PMID: 34861312),
(d) First complete genome sequence of Lumpy Skin Disease virus in India (PMID: 36689139)
(e) First complete genome sequence of Duck Hepatitis A genotype 2 virus in India (GenBank ID: OQ862826).
Publications : Click here
Animal Viral Diseases Laboratory at BRIC-NIAB:
Livestock production is the backbone of global food security, yet it remains under constant siege from infectious diseases—50% of which are viral. With 75% of emerging human infectious diseases originating in animals, studying animal viruses is no longer just a veterinary concern; it is a global health imperative. In our lab, we study viruses, we aim to build the defenses that protect both animal welfare and human lives. Thus, the impact of our work will extend far beyond the farm. Research in Animal Viral Diseases laboratory at NIAB is designed to bridge the gap between fundamental molecular discovery and real-world application through a cohesive, three-pronged strategy: (i) Viral assay biology for developing rapid on farm diagnostics and high throughput antiviral screens (ii) Viral epidemiology and molecular biology to understand and record the circulating/emerging viral strains in India and (iii) Viral biologicals to develop novel, safe and effective next generation vaccines and identification of effective antivirals. All the ongoing projects in the laboratory revolve around these three areas.
We are looking for self-driven, inquisitive PhD candidates who are passionate about molecular biology and eager to master the tools of modern virology. As a member of our team, you will be empowered to lead projects that contribute to a safer, more resilient world. If you are ready to explore the intricacies of viral pathogenesis and develop the biologicals of tomorrow, we welcome your vision and your talent. Interested? then reach out: madhuri@niab.org.in
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