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राष्ट्रीय पशु जैव प्रौद्योगिकी संस्थान
National Institute of Animal Biotechnology
An Autonomous Institute of the Department of Biotechnology,
Ministry of Science and Technology, Government of India
राष्ट्रीय पशु जैव प्रौद्योगिकी संस्थान
National Institute of Animal Biotechnology
An Autonomous Institute of the Department of Biotechnology,
Ministry of Science and Technology, Government of India
Dr. Janani Radhakrishnan completed her M. Sc. (2011) in Biomedical Science (5 year integrated) from Bharathidasan University, India and pursued Ph.D. (2017) at the Centre for Nanotechnology and Advanced Biomaterials (CeNTAB), SASTRA University, Thanjavur, India. Further, she worked at Indian Institute of Technology Madras (IITM), Chennai as institute postdoctoral fellow (2018-2020) and DST INSPIRE faculty fellow at CSIR – Central Leather Research Institute, from December 2020. She has joined NIAB in August 2022.
Awards, Fellowships & Recognition
Early Career Editorial Advisory Board – ACS Biomaterials Science & Engineering
Selected for early career researchers peer review mentoring program (2021) – Nature Communications
https://orcid.org/0000-0002-2805-9122
https://scholar.google.co.in/citations?user=3Bm9IiQAAAAJ&hl=en
3D Biofabrication of Biomaterials for Tissue Engineering and Regenerative Medicine
Dr. Janani Radhakrishnan’s research focus on engineering tissue-mimetic preformed and injectable polymeric scaffolds for regeneration. Tissue engineered scaffolds including injectable hydrogels, random / aligned / core-shell electrospun nanofibers, pneumatic based 3D bioprinted constructs, protein nanoparticles, SPIONs, nanomicellar and nanotheranostic systems have been developed for biomedical application. In particular, an osteochondral mimetic in situ forming hydrogel, with gradient structure, composition and viscoelasticity exhibited cartilage regeneration with restoration of underlying subchondral bone in rabbit full-thickness cartilage defect. A polymer-protein porous microspheres sintered 3D scaffold demonstrated osteogenic regenerative potential in rabbit ulna segmental defect. For peripheral nerve regeneration, axially aligned electrospun nanofibers were investigated as artificial axons and an anatomically equivalent nerve conduit was 3D printed from microcomputed tomography of goat sciatic nerve. Current research interest includes biofabrication of organotypic constructs using 3D bioprinting technology for regenerative medicine and tissue models.
1. Jebakumar M, Pachaiyappan M, Kamini NR, Radhakrishnan J*, Ayyadurai N*. Engineered Spider Silk in Core-Shell Multi-functional Fibrous Mat for Accelerated Chronic Diabetic Wound Healing via Macrophage Polarization. ACS Biomaterials Science and Engineering, 2025, [SCI: 5.5] DOI: 10.1021/acsbiomaterials.5c00737 *Corresponding authors.
2. Pachaiyappan M, Jebakumar M, Radhakrishnan J*, Ayyadurai N*. Electrically Conductive Gellan Gum/Polyvinyl Alcohol Interpenetrating Network Hydrogel: A Dual Crosslinked 3D Printing Ink for Cardiac Tissue. Journal of Materials Chemistry B, 2025, [SCI, IF: 5.7] DOI: 10.1039/D5TB01462J. *Corresponding authors.
3. Valappil S, Mohan I, Radhakrishnan J*, Ayyadurai N*. Building Biomaterials through Genetic Code Expansion. Trends in Biotechnology, 2023, 41: 165-1832022. [SCI, IF: 14.9] *Corresponding authors.
4. Radhakrishnan J, Muthuraj M, Gandham GSPD, Sethuraman S, Subramanian A. Nanohydroxyapatite-Protein Interface in Composite Sintered Scaffold Influences Bone Regeneration in Rabbit Ulnar Segmental Defect. Journal of Materials Science: Materials in Medicine, 2022; 33: 36. [SCI, IF: 4.5]
5. Radhakrishnan J, Varadaraj S, Dash SK, Sharma A, Verma RS. Organotypic Cancer Tissue Models for Drug Screening: 3D Constructs, Bioprinting and Microfluidic Chips. Drug Discovery Today, 2020; 25: 879-890. [SCI, IF: 7.5]
6. Radhakrishnan J, Manigandan A, Chinnaswamy P, Subramanian A, Sethuraman S. Gradient nano-engineered in situ forming composite hydrogel for osteochondral regeneration. Biomaterials, 2018; 162: 82-98. [SCI, IF: 12.9]
7. Radhakrishnan J, Subramanian A, Sethuraman S. Injectable Glycosaminoglycan – Protein Nano–Complex in Semi–Interpenetrating Networks: A Biphasic Hydrogel for Hyaline Cartilage Regeneration. Carbohydrate Polymers, 2017, 175: 63-74. [SCI, IF: 12.5]
8. Radhakrishnan J, Subramanian A, Krishnan UM, Sethuraman S. Injectable and 3D Bioprinted Polysaccharide Hydrogels: From Cartilage to Osteochondral Tissue Engineering. Biomacromolecules, 2017, 18: 1-26. [SCI, IF: 5.4]
9. Radhakrishnan J, Kuppuswamy AA, Sethuraman S, Subramanian A. Topographic cue from electrospun scaffolds regulate myelin–related gene expressions in Schwann cells. Journal of biomedical nanotechnology, 2015, 11: 512-521.
10. Radhakrishnan J, Gandham GSPD, Sethuraman S, Subramanian A. Three-Dimensional Protein Releasing Phase Induced Porous Composite Microspheres Sintered Scaffold for Bone Tissue Engineering. RSC Advances, 2015, 5, 22005 – 22014. [SCI, IF: 4.6]
11. Radhakrishnan J, Krishnan UM, Sethuraman S. Hydrogel based injectable scaffolds for cardiac tissue regeneration. Biotechnology Advances, 2014, 32: 449-461. [SCI, IF: 12.5]
As co-author
12. Zorrón M, Cabrera AL, Sharma R, Radhakrishnan J, Abbaszadeh S, Shahbazi M, Tafreshi OA, Karamikamkar S, Maleki H. Emerging 2D Nanomaterials-Integrated Hydrogels: Advancements in Designing Theragenerative Materials for Bone Regeneration and Disease Therapy. Advanced Science, 2024, 11: 2470185. [SCI, IF: 14.1]
13. Meganathan I, Pachaiyappan M, Aarthy M, Radhakrishnan J, Mukherjee S, Shanmugam G, You J, Ayyadurai N. Recombinants and Genetic Code Expanded Collagen like Protein as a Tailorable Biomaterial. Materials Horizons, 2022, 9: 2698-2721. [IF: 10.7]
14. Banerjee K, Radhakrishnan J, Ayyadurai N, Ganesan P, Kamini NR. Advances in Neoteric Modular Tissue Engineering Strategies for Regenerative Dentistry. Journal of Science: Advanced Materials and Devices, 2022, 100491. [IF: 6.8]
15. Varadaraj S, Kandhasamy S, Kandoi S, Radhakrishnan J, Subramaniam P, Verma RS. Multiple Cues In Acellular Amniotic Membrane Incorporated Embelin For Tissue Engineering. Materials Today Communications, 2022, 104203. [IF: 4.5]
16. Ramesh PA, Dhandapani R, Bagewadi S, Zennifer A, Radhakrishnan J, Sethuraman S, Subramanian A. Reverse engineering of an anatomically equivalent nerve conduit. Journal of Tissue Engineering and Regenerative Medicine, 2021. [SCI, IF: 2.6]
17. Sharma V, Dash SK, Manhas A, Radhakrishnan J, Jagavelu K, Verma RS. Injectable hydrogel for co-delivery of 5-azacytidine in zein protein nanoparticles with stem cells for cardiac function restoration. International Journal of Pharmaceutics, 2021, 603: 120673. [SCI, IF: 5.2]
18. Manigandan A, Handi V, Sundaramoorthy N, Dhandapani R, Radhakrishnan J, Sethuraman S, Subramanian A. Responsive Nanomicellar Theranostic Cages for Metastatic Breast Cancer. Bioconjugate Chemistry, 2018, 29: 275-286. [SCI, IF: 3.9]
19. Soundararajan A, Dhandapani R, Radhakrishnan J, Manigandan A, Kalyanasundaram A, Sethuraman S, Subramanian A. Surface topography of polylactic acid nanofibrous mats: influence on blood compatibility. Journal of Materials Science: Materials in Medicine, 2018, 29: 145. [SCI, IF: 4.5]
20. Tiwari AK, Reddy KS, Radhakrishnan J, Kumar DA, Zehra A, Agawane, SB, Madhusudana K. Influence of antioxidant rich fresh vegetable juices on starch induced postprandial hyperglycemia in rats. Food and function, 2011, 2: 521-8. [SCI-E, IF: 5.4]
Book Chapter
1. Banerjee, K., Ayyadurai, N., Verma, R.S. and Radhakrishnan J*. (2024). Versatile Biomaterials Platform: As Stem Cells Delivery System and Influence Cellular Micro Niche. In: Rama Shanker Verma (ed.) Stem Cell Biology: A Regenerative Perspective. World Scientific Publishing. ISBN: 978-981-12-9488-4. doi: 10.1142/13891. ISBN: 978-981-12-9488-4.
2. Sinduja ME, Mahendiran B, Radhakrishnan J, Arun C, Krishnakumar GS. (2023). Natural Polysaccharide-Based Materials for Scaffolds Biofabrication. In: Maia, F.R.A., Oliveira, J.M., Reis, R.L. (eds) Handbook of the Extracellular Matrix. Springer, Cham. https://doi.org/10.1007/978-3-030-92090-6_29-1. Print ISBN: 978-3-030-92090-6. Online ISBN: 978-3-030-92090-6.
3. Radhakrishnan J, Sethuraman S. Progress in Tissue Engineering Approaches towards Hepatic Diseases Therapeutics. In: Biomaterials and Nanotechnology for Tissue Engineering edited by Sethuraman S, Krishnan UM, Subramanian A. Taylor & Francis Group, CRC press, NY, 2016.
Patents
1. Sethuraman S, Radhakrishnan J, Subramanian A. Spatially Varying In Situ forming Gradient Hydrogel for Osteochondral Tissue Regeneration. [No. 430764]
2. Subramanian A, Sethuraman S, Manigandan A, Radhakrishnan J, Handi V. Responsive Self-assembled Magnetic Micelles for Targeted Metastatic Breast Cancer Theranostics. [No. 453841]
Presentations in conferences (Selected)
1. Sakeena Banu and Radhakrishnan J*. Photocrosslinkable Injectable / Printable Hydrogel for Cardiac Tissue Regeneration. Bioprinting Ignited X India: Biofabrication Progress for the Future of Health, IISc Bengaluru, 2024.
2. Jebakumar M, Pachaiyappan M, Kamini NR, Ayyadurai N*, Radhakrishnan J*. Engineered silk protein-based core-shell electrospun immunomodulatory fibrous scaffold for tissue regeneration with angiogenesis. TERMIS-AP 2022, ICC Jeju, South Korea. In Tissue Engineering Part A(Vol. 28, pp. 655-655). NY 10801 USA: Mary Ann Liebert, Inc.
3. Radhakrishnan J, Manigandan A, Subramanian A, Sethuraman S*. Gradient Nano-Engineered In Situ Forming Hydrogel for Osteochondral Tissue Regeneration in Rabbit. Society for Biomaterials Annual Meeting & Exposition 2017, Minnesota, Minneapolis, US. (Oral presentation)
4. Manigandan A, Handi V, Sundaramoorthy NS, Radhakrishnan J, Dhandapani R, Sethuraman S, Subramanian A. Development of targeted micellar nanotheranostics for metastatic breast cancer. Society for Biomaterials Annual Meeting & Exposition 2017, Minnesota, Minneapolis, US.
5. Radhakrishnan J, Subramanian A, Krishnan UM, Sethuraman S*. Nanohydroxyapatite reinforced injectable semi-interpenetrating network hydrogel for osteoblasts delivery in tissue engineering. ICFNN, January 2016.
6. Radhakrishnan J, Manjula M, Sethuraman S, Subramanian A*. 3D composite porous microsphere sintered scaffold for regeneration of segmental defect in rabbit ulnar bone. Nano India 2015.
7. Radhakrishnan J, Subramanian A, Krishnan UM, Sethuraman S. In Situ Forming Glycosaminoglycan – Protein Nanoparticles Interspersed Semi-Interpenetrating Polymer Networks (SIPNs) for Cartilage Tissue Regeneration. 7th Bangalore India Nano 2014.
Project Fellows:
Sakeena Banu
Souvik Das
Lab Alumni:
Project Fellow:
Nitish Kumar (Currently pursuing PhD at IIT Delhi)
Masters trainees:
Chukka Veena
Kajal Manisha
Akansha Chaudary
Saroj Tadanki (Currently pursuing PhD at NIT Warangal)
1. 3D Bioprinting of Electrically Conducting Hydrogel for Functional Cardiac Tissue Regeneration. (DST – INSPIRE Faculty Fellowship, 2020-2025)
2. 3D Bioprinting Biomimetic Dermo-Epidermal Construct for Skin Tissue Regeneration and Organotypic Tissue Model. (SERB Power grant, 2022-2025)
3. Multi-scale porous construct for bone regeneration and in vitro organotypic functional model. (Indo-German Science and Technology Centre (IGSTC) – Paired early career fellowship in applied research (PECFAR) 2023-2024)
National Institute of Animal Biotechnology
Survey No. 37, Opp. Journalist Colony
Extended Q City Road, Near Gowlidoddy
Gachibowli, Hyderabad
Telangana – 500032
Email: janani[at]niab[dot]org[dot]in
Tel: +91-40-23120178
An Autonomous Institute of the Department of Biotechnology,
Ministry of Science and Technology, Government of India
+91 40 2312 0103
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