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राष्ट्रीय पशु जैव प्रौद्योगिकी संस्थान
National Institute of Animal Biotechnology
An Autonomous Institute of the Department of Biotechnology,
Ministry of Science and Technology, Government of India
राष्ट्रीय पशु जैव प्रौद्योगिकी संस्थान
National Institute of Animal Biotechnology
An Autonomous Institute of the Department of Biotechnology,
Ministry of Science and Technology, Government of India
Dr. Janani Radhakrishnan completed her M. Sc. (2011) in Biomedical Science (5 year integrated) from Bharathidasan University, India and pursued Ph.D. (2017) at the Centre for Nanotechnology and Advanced Biomaterials (CeNTAB), SASTRA University, Thanjavur, India. Further, she worked at Indian Institute of Technology Madras (IITM), Chennai as postdoctoral fellow (2018-2020) and DST INSPIRE faculty fellow at CSIR – Central Leather Research Institute, from December 2020. She has joined NIAB in August 2022.
Awards, Fellowships & Recognition
1) DST – INSPIRE Faculty Fellowship, Duration: 2020-2025
2) Founder Chancellor’s award for Best Ph.D. dissertation of year 2017 for sciences at SASTRA University.
3) Apr 2017: Indo-US Science & Technology Forum (IUSSTF), DST sponsored student visit to the University of Connecticut, US (US Nodal Centre for Orthopaedic Research)
4) July 2015: Japan – Asia SAKURA student exchange program in science, Tokyo City University, Japan
5) INSPIRE Junior & Senior Research Fellowships awarded by DST, Government of India.
6) University First Rank in M.Sc. Biomedical Science, Bharathidasan University, India.
Early Career Editorial Advisory Board
ACS Biomaterials Science & Engineering
Selected for ECR Peer review mentoring program (2021) and Reviewer in Nature Communications
https://orcid.org/0000-0002-2805-9122
https://scholar.google.co.in/citations?user=3Bm9IiQAAAAJ&hl=en
3D Biofabrication of Biomaterials for Tissue Engineering and Regenerative Medicine
Dr. Janani Radhakrishnan’s research focus on engineering tissue-mimetic preformed and injectable polymeric scaffolds for regeneration. Tissue engineered scaffolds including injectable hydrogels, random / aligned / core-shell electrospun nanofibers, pneumatic based 3D bioprinted constructs, protein nanoparticles, SPIONs, nanomicellar and nanotheranostic systems have been developed for biomedical application. In particular, an osteochondral mimetic in situ forming hydrogel, with gradient structure, composition and viscoelasticity exhibited cartilage regeneration with restoration of underlying subchondral bone in rabbit full-thickness cartilage defect. A polymer-protein porous microspheres sintered 3D scaffold demonstrated osteogenic regenerative potential in rabbit ulna segmental defect. For peripheral nerve regeneration, axially aligned electrospun nanofibers were investigated as artificial axons and an anatomically equivalent nerve conduit was 3D printed from microcomputed tomography of goat sciatic nerve. Current research interest includes biofabrication of organotypic constructs using 3D bioprinting technology for regenerative medicine and tissue models.
1. Valappil S, Mohan I, Radhakrishnan J*, Ayyadurai N*. Building Biomaterials through Genetic Code Expansion. Trends in Biotechnology, 2022. [IF: 21.942] *Corresponding authors. (Accepted)
2. Radhakrishnan J, Muthuraj M, Gandham GSPD, Sethuraman S, Subramanian A. Nanohydroxyapatite-Protein Interface in Composite Sintered Scaffold Influences Bone Regeneration in Rabbit Ulnar Segmental Defect. Journal of Materials Science: Materials in Medicine, 2022; 33: 36. [IF: 4.727]
3. Radhakrishnan J, Varadaraj S, Dash SK, Sharma A, Verma RS. Organotypic Cancer Tissue Models for Drug Screening: 3D Constructs, Bioprinting and Microfluidic Chips. Drug Discovery Today, 2020; 25: 879-890. IF: 8.369]
4. Radhakrishnan J, Manigandan A, Chinnaswamy P, Subramanian A, Sethuraman S. Gradient nano-engineered in situ forming composite hydrogel for osteochondral regeneration. Biomaterials, 2018; 162: 82-98. [IF: 15.304]
5. Radhakrishnan J, Subramanian A, Sethuraman S. Injectable Glycosaminoglycan – Protein Nano–Complex in Semi–Interpenetrating Networks: A Biphasic Hydrogel for Hyaline Cartilage Regeneration. Carbohydrate Polymers, 2017, 175: 63-74. [IF: 10.723]
6. Radhakrishnan J, Subramanian A, Krishnan UM, Sethuraman S. Injectable and 3D Bioprinted Polysaccharide Hydrogels: From Cartilage to Osteochondral Tissue Engineering. Biomacromolecules, 2017, 18: 1-26. [IF: 6.978]
7. Radhakrishnan J, Kuppuswamy AA, Sethuraman S, Subramanian A. Topographic cue from electrospun scaffolds regulate myelin–related gene expressions in Schwann cells. Journal of biomedical nanotechnology, 2015, 11: 512-521. [IF: 4.483]
8. Radhakrishnan J, Gandham GSPD, Sethuraman S, Subramanian A. Three-Dimensional Protein Releasing Phase Induced Porous Composite Microspheres Sintered Scaffold for Bone Tissue Engineering. RSC Advances, 2015, 5, 22005 – 22014. [IF: 4.036]
9. Radhakrishnan J, Krishnan UM, Sethuraman S. Hydrogel based injectable scaffolds for cardiac tissue regeneration. Biotechnology Advances, 2014, 32: 449-461. [IF: 17.681]
As co-author
10. Meganathan I, Pachaiyappan M, Aarthy M, Radhakrishnan J, Mukherjee S, Shanmugam G, You J, Ayyadurai N. Recombinants and Genetic Code Expanded Collagen like Protein as a Tailorable Biomaterial. Materials Horizons, 2022. [IF: 15.717] (Accepted)
11. Banerjee K, Radhakrishnan J, Ayyadurai N, Ganesan P, Kamini NR. Advances in Neoteric Modular Tissue Engineering Strategies for Regenerative Dentistry. Journal of Science: Advanced Materials and Devices, 2022, 100491. [IF: 7.382]
12. Varadaraj S, Kandhasamy S, Kandoi S, Radhakrishnan J, Subramaniam P, Verma RS. Multiple Cues in Acellular Amniotic Membrane Incorporated Embelin for Tissue Engineering. Materials Today Communications, 2022, 104203. [IF: 3.662]
13. Ramesh PA, Dhandapani R, Bagewadi S, Zennifer A, Radhakrishnan J, Sethuraman S, Subramanian A. Reverse engineering of an anatomically equivalent nerve conduit. Journal of Tissue Engineering and Regenerative Medicine, 2021. [IF: 4.323]
14. Sharma V, Dash SK, Manhas A, Radhakrishnan J, Jagavelu K, Verma RS. Injectable hydrogel for co-delivery of 5-azacytidine in zein protein nanoparticles with stem cells for cardiac function restoration. International Journal of Pharmaceutics, 2021, 603: 120673. [IF: 6.510]
15. Manigandan A, Handi V, Sundaramoorthy N, Dhandapani R, Radhakrishnan J, Sethuraman S, Subramanian A. Responsive Nanomicellar Theranostic Cages for Metastatic Breast Cancer. Bioconjugate Chemistry, 2018, 29: 275-286. [IF: 6.069]
16. Soundararajan A, Dhandapani R, Radhakrishnan J, Manigandan A, Kalyanasundaram A, Sethuraman S, Subramanian A. Surface topography of polylactic acid nanofibrous mats: influence on blood compatibility. Journal of Materials Science: Materials in Medicine, 2018, 29: 145. [IF: 4.727]
Book Chapter
1. Radhakrishnan J, Sethuraman S. Progress in Tissue Engineering Approaches towards Hepatic Diseases Therapeutics. In: Biomaterials and Nanotechnology for Tissue Engineering edited by Sethuraman S, Krishnan UM, Subramanian A. Taylor & Francis Group, CRC press, NY, 2016.
Patents
1. Sethuraman S, Radhakrishnan J, Subramanian A. Spatially Varying In Situ forming Gradient Hydrogel for Osteochondral Tissue Regeneration. [Ref. No. 201641042654] (In order for grant – Awaiting NBA approval)
2. Subramanian A, Sethuraman S, Manigandan A, Radhakrishnan J, Handi V. Responsive Self-assembled Magnetic Micelles for Targeted Metastatic Breast Cancer Theranostics. [Ref. No. 201641023450] (Reply Filed. Application in amended examination)
Presentations in conferences (Selected)
1. Radhakrishnan J, Manigandan A, Subramanian A, Sethuraman S*. Gradient Nano-Engineered In Situ Forming Hydrogel for Osteochondral Tissue Regeneration in Rabbit. Society for Biomaterials Annual Meeting & Exposition 2017, Minnesota, Minneapolis, US. (Oral presentation)
2. Manigandan A, Handi V, Sundaramoorthy NS, Radhakrishnan J, Dhandapani R, Sethuraman S, Subramanian A. Development of targeted micellar nanotheranostics for metastatic breast cancer. Society for Biomaterials Annual Meeting & Exposition 2017, Minnesota, Minneapolis, US.
3. Radhakrishnan J, Subramanian A, Krishnan UM, Sethuraman S*. Nanohydroxyapatite reinforced injectable semi-interpenetrating network hydrogel for osteoblasts delivery in tissue engineering. ICFNN, January 2016.
4. Radhakrishnan J, Manjula M, Sethuraman S, Subramanian A*. 3D composite porous microsphere sintered scaffold for regeneration of segmental defect in rabbit ulnar bone. Nano India 2015.
5. Radhakrishnan J, Subramanian A, Krishnan UM, Sethuraman S. In Situ Forming Glycosaminoglycan – Protein Nanoparticles Interspersed Semi-Interpenetrating Polymer Networks (SIPNs) for Cartilage Tissue Regeneration. 7th Bangalore India Nano 2014.
Invited Lectures
1. Jan 2022: Lecture in AICTE – ISTE sponsored Induction / Refresher Programme on ‘Nanotechnology in Healthcare’ organized by PSG College of Technology, Coimbatore.
2. Dec 2021: Talk titled ‘Injectable Nano-engineered Hydrogels for Functional Tissue Regeneration’ at The Third Indian Materials Conclave and the 32nd Annual General Meeting of Materials Research Society India (MRSI), December 20-23, 2021. (Invited Speaker)
3. Aug 2020: Lecture in AICTE approved QIP Workshop on ‘Recent advances in Stem Cells and Tissue Engineering’ organized by Department of Biotechnology, IIT Madras, Chennai
4. Aug 2020: Lecture on ‘Important aspects of Nanotechnology for Biomedical Applications & 3D Bioprinting’ in a webinar series ‘Cognizance – 2020’ conducted by PSG College of Technology, Coimbatore.
5. Jan 2019: Lecture in AICTE approved QIP Workshop on ‘Recent advances in Biotechnology related to tissue engineering’ organized by Department of Biotechnology, IIT Madras, Chennai
6. April 2019: ASIA LABEX 2019 conducted by Fenza Exhibitions pvt ltd. (LABOTICA 2019 Seminar with IIT Madras).
1. 3D Bioprinting of Electrically Conducting Hydrogel for Functional Cardiac Tissue Regeneration. (DST – INSPIRE Faculty Fellowship, 2020-2025)
2. 3D Bioprinting Biomimetic Dermo-Epidermal Construct for Skin Tissue Regeneration and Organotypic Tissue Model. (SERB Power grant, 2022-2025)
National Institute of Animal Biotechnology
Survey No. 37, Opp. Journalist Colony
Extended Q City Road, Near Gowlidoddy
Gachibowli, Hyderabad
Telangana – 500032
Email: janani[at]niab[dot]org[dot]in
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