Menu
राष्ट्रीय पशु जैव प्रौद्योगिकी संस्थान
National Institute of Animal Biotechnology
An Autonomous Institute of the Department of Biotechnology,
Ministry of Science and Technology, Government of India
राष्ट्रीय पशु जैव प्रौद्योगिकी संस्थान
National Institute of Animal Biotechnology
An Autonomous Institute of the Department of Biotechnology,
Ministry of Science and Technology, Government of India
Education
B.Vet. Sc. & A. H. (equivalent to DVM)/ 1996
Jawaharlal Nehru Krishi Vishwa Vidyalaya, Jabalpur, India
Major: Veterinary Sciences and Animal Husbandry
M. Vet. Sc. / 2000
Tamil Nadu Veterinary and Animal Sciences University, Chennai, India
Major: Animal Biotechnology
Thesis: Effect of Growth Factors on In Vitro Development of Sheep oocytes
Ph.D. / 2008
Kyoto University, Kyoto, Japan
Major: Applied Biosciences/Reproductive Biology
Thesis: Identification, Stem Cell Potential and In Vitro Cultivation of Primitive Germ Cells from Neonatal Porcine Testis
Editorial Board Member
Editorial board member of Scientific Reports, an online, open-access journal from the publishers of Nature. It publishes scientifically valid primary research from all areas of the natural and clinical sciences.
Appointments
1. Scientist F, DBT- National Institute of Animal Biotechnology (NIAB, Hyderabad, India
Joined on 06 August 2020 and continuing
2. Senior Principal Scientist, CSIR-Centre for Cellular and Molecular Biology (CCMB), Hyderabad
June 2018-August 2020
3. Principal Scientist, CSIR-Centre for Cellular and Molecular Biology (CCMB), Hyderabad India
June 2011-June 2018
4. Senior Scientist, CSIR-Centre for Cellular and Molecular Biology (CCMB), Hyderabad India
June 2007-June 2011
5. Scientist, CSIR-Centre for Cellular and Molecular Biology (CCMB), Hyderabad India
June 2003-June 2007
6. Junior Scientist, CSIR-Centre for Cellular and Molecular Biology (CCMB), Hyderabad India
June 2000-June 2003
7. Visiting Scientist, Georgetown University School of Medicine, Washington DC, USA
October 2012-March 2013 (on deputation)
8. Associate Professor, Kyoto University, Kyoto, Japan (tenure-track)
March 2017 – March 2019 (on lien)
Professional training
1. Production of transgenic and gene knock out animals. National Institute of Immunology (NII), Department of Biotechnology (DBT), New Delhi, India, 2001.
2. Hands-on Training on Cloning Research for Quality Animal Production. National Dairy Research Institute (NDRI), Indian Council of Agriculture Research (ICAR), Karnal, Haryana, India, 2011.
Professional membership
1. Life member, International Society for Stem cell Research (ISSCR)
2. Life member, Indian Society for Study on Reproduction and Fertility (ISSRF).
3. Life member, Association of the Promotion of DNA Finger Printing and other DNA Technologies (ADNAT).
4. Life member, Indian Society for Veterinary Immunology and Biotechnology (ISVIB).
Awards
1. University Gold Medal (B.V.Sc. & A.H.) for outstanding academic performance
2. P.K. Pathwardhan Silver Medal (B.V.Sc. & A.H.), a sponsor’s medal for excellent academic performance
3. Department of Biotechnology (DBT), Government of India, fellowship for pursuing an M.V.Sc. program in Animal Biotechnology
4. Qualified National Eligibility Test (NET) 1999 – Indian Council of Agriculture Research (ICAR)
5. Japanese Government Monbukagakusho (MEXT) scholarship, 2005 for the Ph.D. studies at Kyoto University, Kyoto, Japan.
6. Asia-Pacific Developmental Biology Network (APDBN) travel award for attending the 4th Annual Conference of Asian Reproductive Biotechnology Society held at the National University of Singapore.
7. Excellent poster award at the 4th Annual Conference of Asian Reproductive Biotechnology Society held at the National University of Singapore, Singapore.
8. International Society for Stem Cell Research (ISSCR) travel grant for attending the 6th ISSCR annual meeting held at Philadelphia, USA
9. CSIR travel award for attending the 6th ISSCR annual meeting held at Philadelphia, USA
10. International Congress on Animal Reproduction (ICAR) grant (travel, accommodation, and registration) for attending and presenting a poster at the 16th ICAR held at Budapest, Hungary.
11. Asia-Pacific Developmental Biology Network (APDBN) travel award for attending the 5th Annual Conference of Asian Reproductive Biotechnology Society (ARBS) held at Kunming, China.
12. Indo-US Science and Technology Forum (IUSSTF) Fellowship, 2012 for visiting researcher at Georgetown University Medical School, Washington DC, USA.
Publons profile: https://publons.com/researcher/1503404/sandeep-goel/List of Publications (Papers): (In national and international peer-reviewed journals)
1. Goel S, Gandhi S, Dubey S, Shah M, Saini S, Arora P, Prakashan D, Shukla S and Sharma GT (2023) Stem Cell Therapy: Promises and Challenges in Treating Animal Diseases. In Biotechnological Interventions Augmenting Livestock Health and Production. Springer Nature DOI: 10.1007/978-981-99-2209-3.
2. Mahla RS, Goel S Jainarayanan A, Jainarayanan A, Kumar N and Shukla R (2023) Germline Stem Cell Technology in Fertility Preservation. In Handbook of Stem Cell Applications. Springer Nature DOI: 10.1007/978-981-99-0846-2_28-1.
3. Devi L and Goel S (2022). Spermatogonial stem cells and testis-tissue cryopreservation as a tool for conservation of buffalo germplasm. In Biotechnological Applications in Buffalo Research. Springer Nature (DOI: 10.1007/978-981-16-7531-7).
4. Miki Y, Devi L, Imai Y, Koide T, Minami N and Goel S* (2020). Male fertility is not impacted by the deletion of the PDZ-binding kinase (Pbk) gene in mice. Reproduction Fertility and Development 32 (10):893-902.
5. Goel S*and Minami N (2019). Altered hormonal milieu and dysregulated protein expression can cause spermatogenic arrest in ectopic xenografted immature rat testis. Scientific Reports 9 (1), 4036.
6. Devi L, Pothana L and Goel S* (2017). Dysregulation of angiogenesis-specific signaling in adult testis results in xenograft degeneration. Scientific Reports 7 (1), 2605.
7. Pothana L, Devi L and Goel S *(2017) Cryopreservation of adult cervid testes. Cryobiology 74, 103-109.
8. Pothana L, Devi L, Venna NK, Pentakota N, Varma VP, Jose J and Goel S* (2016). Replacement of serum with ocular fluid for cryopreservation of immature testes. Cryobiology 73 (3), 356-366.
9. Pothana L, Venna NK, Devi L, Singh A, Chatterjee I and Goel S* (2016). Cryopreservation of adult primate testes. European Journal of Wildlife Research. 62 (5), 619-626.
10. Devi L and Goel S* (2016). Fertility preservation through gonadal cryopreservation. Reproductive Medicine and Biology. 15(4): 235–251 (invited review article).
11. Devi L and Goel S (2016). Conservation of Germplasm of Livestock through Gonadal Cryopreservation. In Innovation Designs, Implements for Global Environment and Entrepreneurial Needs Optimising Utilitarian Sources, INDIGENOUS, International Livestock Conference & Expo, 23rd Annual Convection ISPAM, Hyderabad Reddy SR, Prasad RMV and Rao AR (Eds.), pp 377-389, ISBN No. 978-93-84869-99-1, Excel India Publishers.
12. Varma VP, Devi L, Venna NK, Murthy CLN, Idris MM and Goel S* (2015). Ocular fluid as a replacement for serum in cell cryopreservation media. PloS one 10 (7), e131291.
13. Makala H, Pothana L, Sonam S, Malla and Goel S* (2015). Regeneration of Leydig cells in ectopically autografted adult mouse testes. Reproduction 49 (3), 259-268.
14. Pothana L, Makala H, Devi L, Varma V and Goel S* (2015). Germ cell differentiation in cryopreserved immature Indian spotted mouse deer (Moschiola indica) testes xenografted onto mice. Theriogenology 83 (4), 625-633.
15. Devi L, Pawar R, Makala H and Goel S* (2015). Conserved expression of ubiquitin carboxyl-terminal esterase l1 (uchl1) in mammalian testes. Indian Journal of Experimental Biology 53: 305-312 PubMed PMID: 2604002.
16. Devi L, Makala H, Pothana L, Nirmalkar K and Goel S* (2014). Comparative efficacies of six different media for cryopreservation of immature buffalo calf (Bubalus bubalis) Testis. Reproduction Fertility and Development 28 (7), 872-885.
17. Reddy N, Sreshtha S, Katakam M, Ashwini M, Sonam S, Kumar V and Goel S *(2013). Prepubertal buffalo (Bubalus bubalis) Leydig cells: isolation, culture, and characterisation. Journal of Buffalo Science 2, 25-33.
18. SinghVP, Lakshmi BJ, Singh S, Shah V, Goel S, Sarathi DP and Kumar S (2012). Lack of Wdr13 gene in mice leads to enhanced pancreatic beta cell proliferation, hyperinsulinemia, and mild obesity. PloS one 7 (6), e38685.
19. Mahla R, Reddy N and Goel S* (2012). Spermatogonial stem cells (SSCs) in buffalo
(Bubalus bubalis) testis. PLoS One 7 (4), e36020.
20. Reddy N, Mahla RS, Thati R, Suman SK, Jose J and Goel S* (2012). Gonadal status of male recipient mice influences the germ cell development in immature buffalo testis tissue xenograft. Reproduction 135 (6), 785-796.
21. Reddy N, Kasukurthi KB, Mahla RS, Pawar RM and Goel S* (2012). Expression of vascular endothelial growth factor (VEGF) transcript and protein in the testis of several vertebrates including endangered species. Theriogenology 77: 608-614.
22. Goel S*, Reddy N, Mahla RS, Suman SK, and Pawar RM (2011). Spermatogonial stem cells in the testis of an endangered bovid: Indian blackbuck (Antilope cervicapra L.). Animal Reproduction Science 126: 251-257.
23. Goel S*, Mahla RS, Suman SK, Reddy N and Imai H (2010). UCHL-1 protein expression specifically marks spermatogonia in wild bovid testis. European Journal of Wildlife Research 57: 663-667.
24. Goel S*, Reddy N, Mandal S, Kim S, Fujihara M and Imai H (2010). Spermatogonia-specific proteins expressed in prepubertal buffalo (Bubalus bubalis) testis and their utilisation for isolation and in vitro cultivation of spermatogonia. Theriogenology 74: 1221-1232.
25. Goel S, Fujihara M, Tsuchiya K, Takagi Y, Minami N, Yamada M and Imai H (2009). Multipotential ability of primitive germ cells from neonatal pig testis cultured in vitro. Reproduction Fertility and Development 21: 696-708.
26. Fujihara M, Goel S, Kimura Y, Minami N, Yamada M and Imai H (2008). 72 Preservation of porcine gonocytes at 4° c and in liquid nitrogen–a preservation model of genetic resources in domestic animals and in endangered species. Reproduction, Fertility and Development 20 (1), 117.
27. Goel S, Fujihara M, Minami N, Yamada M and Imai H (2008). NANOG is expressed by the progenitor-type stem cells and differentiated germ cells in pig testis. Reproduction in Domestic Animals 43, 217.
28. Fujihara M, Goel S, Minami N, Yamada M and Imai H (2008). In vivo and in vitro preservation of primitive germ cells from neonatal pig testis. Reproductive Medicine and Biology 7: 153- 160.
29. Goel S, Fujihara M, Minami N, Yamada M and Imai H (2008). Expression of NANOG, but not POU5F1, points to the stem cell potential of primitive germ cells in neonatal pig testis. Reproduction 135: 785-795.
30. Goel S, Sugimoto M, Minami N, Yamada M, Kume S and Imai H (2007). 146 Lectin dolichos biflourus agglutinin (DBA) is a specific marker for primitive germ cells in neonatal porcine testis. Reproduction, Fertility and Development 19 (1), 190.
31. Devi L, Pothana L and Goel S* (2017). Dysregulation of angiogenesis-specific signaling in adult testis results in xenograft degeneration. Scientific Reports 7 (1), 2605. (IF: 4.52; HI: 149) (*Corresponding author)
32. Goel S* and Minami N (2019). Altered hormonal milieu and dysregulated protein expression can cause spermatogenic arrest in ectopic xenografted immature rat testis. Scientific Reports 9 (1), 4036. (IF: 4.52; HI: 149) (*Corresponding author)
33. Miki Y, Devi L, Imai Y, Koide T, Minami N and Goel S* (2020). Male fertility is not impacted by the deletion of the PDZ-binding kinase (Pbk) gene in mice. Reproduction Fertility and Development 32 (10):893-902. doi: 10.1071/RD19445. (IF: 1.72; HI: 68) (*Corrosponding author).
34. Alex J L, Sarathi D P, Goel S and Kumar S (2005). Isolation and characterisation of a mouse embryonic stem cell line that contributes efficiently to the germline. Current Science. 88(7) 1167-1169
35. Ajaikumar KB, Nair HB, Goel S, Alex JA, Parachuri V, Patel KB, and Padikkala J (2004). Manipulation of the mouse genome and its application in biomedical research. Amala Research Bulletin 24: 224-245 (ISSN No. 0971-4987).
36. Goel S, Palanisamy A and Nainer M (2004). Development of sheep embryos in vitro: effect of insulin and insulin-like growth factor (IGF-I). Indian Journal of Animal Sciences 74(4) 341-344.
37. Singh BN, Suresh A, UmaPrasad G, Subramanian S, Sultan M, Goel S, Kumar S, and Singh L (2003). A highly conserved human gene encoding a novel member of WD-repeat family of protein (WDR13). Genomics. 81 (3), 315-328.
List of Publications (Abstracts)
1. Goel S (2019). Testis tissue cryopreservation and xenografting as tools for the conservation of endangered species. International Conference in Advancement in Veterinary Sciences for Wildlife Conservation and 13th Annual Meeting of Association of Indian Zoo and Wildlife Veterinarians, CSIR-Centre for Cellular and Molecular Biology, Hyderabad, India, 13-15 November 2019.
2. Goel S (2018). Testis tissue cryopreservation and xenografting as tools for the conservation of endangered species. The 8th International Seminar on Biodiversity and Evolution, Kyoto, Japan.
3. Goel S, Devi L and Pothana L (2017). Impaired Angiogenesis-specific Signaling in Adult Testis Results in Xenograft Degeneration. The International Symposium on Regulation of Germ Cell Development in vivo and in vitro. Centennial Hall, Kyushu University, School of Medicine Fukuoka, Japan.
4. Biswa BB, Devi L, Pothana L, Iyer S, Ghoshal T and Goel S (2017). Role of testis-specific kinase PBK/TOPK in spermatogenesis. International Conference on Reproductive Health with Emphasis on Strategies for Infertility, Assisted Reproduction and Family Planning, New Delhi, India.
5. Goel S, Devi L, Pothana L and Varma V (2015). Can results from cryopreservation of livestock testis be extrapolated to germplasm conservation of endangered species? International Conference on Low-Temperature Science and Biotechnological Advances, New Delhi, India.
6. Goel S (2014). Buffalo (Bubalus bubalis) testis: Protein expression, stem cell potential and alteration of spermatogenesis in xenogenic host. The International Conference on Reproductive Health: Issues and Strategies under Changing Climatic Scenario, IVRI, Izatnagar, Bareilly, India, February 6-8, 2014.
7. Kim SM, Fujihara M, Goel S, Sahare M, Minami N, Yamada M and Imai H (2011). Identification of reprogramming factors associated with a pluripotent potential of porcine and bovine spermatic stem cells in culture. 16th World Congress on In-Vitro Fertilization and 5th World Congress in In-Vitro Maturation, Tokyo, Japan.
8. Reddy N, Mahla RS, Suman SK, Pawar RM and Goel S (2011). Stem Cell Potential of Spermatogonial Stem Cells (SSCs) in an Endangered Bovid: Indian Black Buck (Antelope cervicapra L.). 8th Indo-Australia Biotechnology Conference on “Stem Cell Biology”, JNCASR, Bangalore, India.
9. Kim S, Fujihara M, Goel S, Minami N, Yamada M, Imai H (2010). Lectin DBA specifically recognises glycan cell surface epitope of gonocytes in developing mouse testis. 11th International Symposium on Spermatology, Okinawa, Japan.
10. Goel S, Mandal S, Reddy N, Mahla RS, Suman SK, Raj A, Kim S, Fujihara M and Imai H (2010). Stem cells of the male germline: An aid to the conservation of endangered species. 11th International Symposium on Spermatology, Okinawa, Japan.
11. Mahla RS, Suman SK, Reddy N and Goel S (2010) Generation of vascular endothelial growth factor (VEGF) expressing cell line to aid in testis xenograft survival. International Conference on Stem Cells and Cancer (ICSCC), Pune, India.
12. Goel S, Fujihara M, Tsuchiya K, Takagi Y, Minami N, Yamada M, Imai H (2009). Multipotency of cultured germ cells isolated from neonatal pig testis.27th International Conference on Novel Updates in Reproductive Biology and Comparative Endocrinology, University of Hyderabad, India.
13. Goel S, Fujihara M, Tsuchiya K, Takagi Y, Minami N, Yamada M, Imai H (2008). Multipotency of in vitro cultured primitive germ cells isolated from neonatal pig testis. 5th Annual conference of Asian Reproductive Biotechnology Society (ARBS), Kunming, China.
14. Goel S, Fujihara M, Tsuchiya K, Takagi Y, Minami N, Yamada M, Imai H (2008). Germ cells from neonatal pig testis acquire multipotent characteristic in vitro. 6th Annual Meeting of International Society for Stem Cell Research (ISSCR), Philadelphia, USA.
15. Goel S, Fujihara M, Minami N, Yamada M, Imai H (2008). NANOG is expressed by the progenitor-type stem cells and differentiated germ cells in pig testis. Reprod Domestic Anim 43, 217. 16th International Congress of Animal Reproduction (ICAR) Budapest, Hungary.
16. Fujihara M, Goel S, Minami N, Yamada M, Imai H (2009). Characterisation and Cultivation of Gonocytes In Vitro Derived from Bovine Neonatal Testes. 7th Annual Meeting of International Society for Stem Cell Research (ISSCR), Barcelona, Spain.
17. Fujihara M, Goel S, Kimura Y, Minami N, Yamada M, Imai H (2008). Preservation of porcine gonocytes at 4°C and in liquid nitrogen – a preservation model of genetic resources in domestic animals and in endangered species. Reprod Fertil Dev 20 (1): 117. 34th International Embryo Transfer Society (IETS) Annual Meeting, Denver, Colorado, USA.
18. Goel S, Sugimoto M, Minami N, Yamada M, Kume S, Imai H (2007) Lectin Dolichos biflorous agglutinin (DBA) is a specific marker for primitive germ cells in neonatal porcine testis. Reprod Fertil Dev 19 (1): 190. 33rd International Embryo Transfer Society (IETS) Annual Meeting, Kyoto, Japan.
19. Rani SD, Goel S, Alex JL, Sarathi DP and Kumar S (2003).Generation of kappa-casein gene-deficient mouse through gene targeting in embryonic stem cells. 10th Congress of Federation of Asian and Oceanian Biochemists and Molecular Biologist (FAOBMB), Indian Institute of Sciences (IISc), Bangalore, India.
20. Goel S, Palanisamy A and Nainar M (2000) Effect of Insulin and Insulin-like Growth Factor (IGF-I) on In vitro Development of Sheep Embryo. International Congress on Fertilization, Embryo Development, and Implantation, National Institute of Immunology (NII), New Delhi, India.
Conference proceedings
1. Saini S, Arora P, Dalabehara S and Goel S (2022).Mesenchymal stem cells therapy: an Indian perspective. In Recent Advances in Stem Cell Biology and Therapeutics, Deepa Bhartiya and Vikash Chandra (Eds.) PP 9-12, 29th ISSRF Newsletter (ISSN: 2395:2806).
2. Goel S (2022). Spermatogonial stem cells can aid in conservation of germplasm of prized and endangered animals. In Recent Advances in Stem Cell Biology and Therapeutics, Deepa Bhartiya and Vikash Chandra (Eds.) PP 43-45, 29th ISSRF Newsletter (ISSN: 2395:2806).
Popular Articles
1. Goel S and Kumar S (2005). Avian Transgenics: An Industrial Perspective, http://www.poulvet.com/poultry/articles/3.php. Indian Poultry Science Association and National Symposium (IPSACON).
Media Coverage
1. Stemming the tides, The Telegraph, July 11, 2011. http://www.telegraphindia.com/1110711/jsp/knowhow/story_14222109.jsp
Technical Manual
1. Collection of the testis from dead animals for germplasm preservation (2017). Manual for biological sample collection and preservation for genetic, reproductive, and disease analysis. Central Zoo Authority, Govt. of India.
PhD Students
Ibraz Kori, DBT-JRF
MSc (Biotechnology), Jamia Millia Islamia (2021)
Research Interest: Developing mesenchymal stem cell-based therapy for livestock diseases
Project Fellows
Michelle Abraham
MSc (Stem Cell Technology and Regenerative Biology), Manipal Institute of Regenerative Medicine (MAHE), Manipal (2021)
Research Interest: Developing mesenchymal stem cell-based therapy for livestock diseases
Lab Alumni
Parvathy S. Nair
Short-term Trainee
M.Sc. (Biotechnology), Amrita Vishwa Vidyapeetham
Anjali Parihar
Short-term Trainee
Tech (Microbiology), ITM University
Past Members
Pragati Singh
MSc dissertation trainee (2021-22)
Central Univesity of South Bihar
Swati Shukla
MSc dissertation trainee (2021-22)
Devi Ahilya Vishwavidyalaya
Inagandla Bhargav
MSc dissertation trainee (2021-22)
Mysore University
As Principal Investigator
1. Adipose tissue-derived mesenchymal stem cells for therapy in livestock Species, DBT, Government of India (GoI).
2. Conservation of Endangered Species with an Emerging Technology: Exploiting the Male Germ Line Stem Cells, DBT, Government of India (GoI).
3. Preservation of Endangered Species and their Genetic Resources by Biotechnological Interventions, DST, GoI.
4. Ectopic expression of vascular endothelial growth factor (VEGF): Implication in testis xenograft survival and development, CSIR, GoI.
5. Conservation of Endangered Animals based on Genetic Polymorphism Studies and Assisted Reproduction, CZA, GoI.
6. Conservation of Endangered Animals of India: Molecular Genetics and Reproductive Approach, CSIR, GoI.
7. Isolation, characterization, and culture of human male germline stem cells, IUSSTF
8. Regulation and the role of serine-threonine protein kinase (PBK/TOPK) in spermatogenesis, JSPS, Govt. of Japan.
As Co-PI and Team Member
1. X-Chromosome: Functional genomics approach, CSIR, GoI.
2. Establishment of a national facility on transgenic and gene knockout mice, DBT, GoI.
3. Targeted Deletion of Casein Gene Family in Mouse, CSIR, GoI.
4. Functional Analysis of Mouse Wdr13 Gene, CSIR, GoI.
Room 215, 2nd Floor, C Wing
National Institute of Animal Biotechnology
Survey No. 37, Opp. Journalist Colony
Extended Q City Road, Near Gowlidoddy
Gachibowli, Hyderabad
Telangana – 500032
Email: goel[at]niab[dot]org[dot]in
Tel: +91-(0)40-2312-0155
Highlights
1. Establishment of the adipose and amniotic membrane-derived mesenchymal stem cell line in goats.
2. Development of a robust culture system for the mesenchymal stem cells.
3. Establishment of their long-term cryopreservation for bio-banking.
Looking for motivated students (for PhD and dissertation program) and post-doctoral scientists to work towards a holistic approach to “Animal Health and Human Welfare”. Please contact me with a CV and a cover page.
An Autonomous Institute of the Department of Biotechnology,
Ministry of Science and Technology, Government of India
+91 40 2312 0103
admin[at]niab[dot]org[dot]in
© National Institute of Animal Biotechnology (NIAB)
Made with ❤ by NIAB